肺动脉高压发生机制及治疗药物的研究进展
Progress in pathogenesis and therapeutic drugs of pulmonary arterial hypertension
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摘要: 肺动脉高压(PAH)是一种以肺血管阻力和肺动脉压力渐进性升高为特征,最终导致患者右心衰竭而死亡的疾病。本文综述了近年来有关PAH发生的细胞和分子机制及其治疗药物的研究进展。Abstract: Pulmonary arterial hypertension(PAH) is a progressive and fatal disease,characterized by elevated pulmonary vascular resistance and pulmonary arterial pressure,most often resulting in right-sided heart failure.The mechanisms of action,approved PAH therapies and the latest agents in late-stage clinical development were reviewed and described in this paper.