药物分布容积的预测方法

基金项目: 江苏省药代动力学重点实验室提升项目(No.BM2012012)

Methods for prediction of drug distribution volume

摘要: 药物在体内的分布程度，包括药物分布容积和组织分配比，对于预测其疗效和不良反应起重要作用。由于伦理原因，上述两个参数无法直接在人体进行试验获取。因此，开发准确预测药物人体分布容积和组织-血液分配比的方法具有十分重要的意义。本文综述了基于经验、半机制和基于生理机制的方法预测药物人体稳态分布容积的研究及其进展。
- 分布容积 /
- 组织血液分配比 /
- 预测 /
- 生理机制模型
Abstract: The extent of drug distribution in body, including volume of distribution and tissue-to-plasma partition coefficients, is an important indicator to evaluate drug efficacy and adverse effect. Considering the ethical issue, the two parameters can not be directly measured in human, therefore, it is significant to predict the volume of distribution and the tissue-to-plasma partition coefficients accurately. This paper reviewes recent developments in prediction of volume of distribution at steady-state based on empirical method, half-mechanistic method and physiologically-based pharmacokinetic model, respectively.
- volume of distribution /
- tissue-to-plasma partition coefficients /
- prediction /
- physiologically-based pharmacokinetic model