Abstract: Twelve compounds were isolated and purified from the ethanol extract of Coptis teeta wall by various chromatographic methods, and their structures were elucidated by spectral techniques and physicochemical properties as 3, 5, 7-trihydroxy- 6, 8-dimethylflavone( 1 ), ferulic acid( 2 ), Z-octadecyl caffeate( 3 ), protocatechuic acid( 4 ), methyl-3, 4-dihydroxyphenyl lactate( 5 ), 3, 4-dihydroxyphenethyl alcohol( 6 ), 3, 5-dihydroxyphenethyl alcohol-3-O-β-D-glucopyranoside( 7 ), (+)-lariciresinol( 8 ), woorenoside I( 9) , woorenoside II( 10 ), longifolroside A( 11 )and(+)-syringaresinol-4-O-β-D-glucopyranoside( 12 ). Compounds 1 , 4 , 7 , 11 were isolated from this genus for the first time. All the compounds were isolated from this plant for the first time.