抗肿瘤香豆素类化合物的研究进展

基金项目: 中央高校基本科研业务费专项基金资助项目(No.JKZ2011016)

Progress in the study of coumarin derivatives as antitumor agents

摘要: 香豆素广泛存在于自然界，具有抗肿瘤、抗感染、抗病毒及抗菌等多种生物活性，且其抗肿瘤活性常具有肿瘤细胞高选择性和对正常细胞低毒性的特点；但天然香豆素往往存在活性不理想、水溶性较差或生物利用度低等缺陷，导致其临床应用受到限制，因此对其进行结构修饰、改造及构效关系研究成为相关领域研究的热点。本文综述了近年来抗肿瘤香豆素类化合物的研究进展。
- 香豆素 /
- 抗肿瘤 /
- 结构修饰 /
- 构效关系
Abstract: Coumarins are a class of compounds with multiple biological activities such as antitumor, anti-inflammatory, anti-virus, and anti-bacterial properties. The anti-tumor activity is of high selectivity and low toxicity, however, the clinical use of natural coumarins is often restricted by their less bioactivity, poorer water-solubility and lower bioavailability. Therefore, the structural modification and structure-activity relationship of coumarins have become a research hotspot. The recent progress in the studies of coumarin derivatives with antitumor activities is reviewed in this paper.
- coumarin /
- antitumor /
- structural modification /
- structure-activity relationship

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