Abstract: In the past decade, more maturing nanocrystal technology brought about commercial marketing of ten kinds of nanocrystal formulation. The saturated solubility, dissolution rate and oral bioavailability could be improved. Emergence of new equipments and materials ensured the controllability and industrialization in the adaptation of nanocrystal technology. Nanocrystal formulations for the different routes of administration are available or in clinical investigation. This paper summarized the industrial production methods, the key processing parameters, the effects of stability-enhancer on the nanocrystal formulations, and the drugs on the market or in clinical study.