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丹红化瘀口服液联合胰岛素对早期糖尿病肾病的防治作用（英）

钟春梅, 马燕, 王延东, 杨威, 韩重, 孙晶晶, 林宝琴

钟春梅, 马燕, 王延东, 杨威, 韩重, 孙晶晶, 林宝琴. 丹红化瘀口服液联合胰岛素对早期糖尿病肾病的防治作用（英）[J]. 中国药科大学学报, 2013, 44(6): 568-572. DOI: 10.11665/j.issn.1000-5048.20130616
引用本文: 钟春梅, 马燕, 王延东, 杨威, 韩重, 孙晶晶, 林宝琴. 丹红化瘀口服液联合胰岛素对早期糖尿病肾病的防治作用（英）[J]. 中国药科大学学报, 2013, 44(6): 568-572. DOI: 10.11665/j.issn.1000-5048.20130616
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ZHONG Chunmei, MA Yan, WANG Yandong, YANG Wei, HAN Zhong, SUN Jingjing, LIN Baoqin. Effect of Danhong Huayu Koufuye combined with insulin on prevention and progression of early diabetic nephropathy in rats[J]. Journal of China Pharmaceutical University, 2013, 44(6): 568-572. DOI: 10.11665/j.issn.1000-5048.20130616
Citation: ZHONG Chunmei, MA Yan, WANG Yandong, YANG Wei, HAN Zhong, SUN Jingjing, LIN Baoqin. Effect of Danhong Huayu Koufuye combined with insulin on prevention and progression of early diabetic nephropathy in rats[J]. Journal of China Pharmaceutical University, 2013, 44(6): 568-572. DOI: 10.11665/j.issn.1000-5048.20130616
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丹红化瘀口服液联合胰岛素对早期糖尿病肾病的防治作用（英）

  • 1.

    广州中医药大学中药学院

  • 2.

    中山大学中山眼科中心

  • 3.

    广州医药研究总院有限公司

  • 4.

    美国太平洋大学药剂学与健康学院

基金项目: 国家自然科学基金资助项目(No.81303282)；广州市珠江科技新星专项资助项目(No.2013J2200034)；广州中医药大学青年英才培养资助项目

Effect of Danhong Huayu Koufuye combined with insulin on prevention and progression of early diabetic nephropathy in rats

摘要

    摘要
  • 摘要: 丹红化瘀口服液是传统中药复方，具活血化瘀、行气通络的功效。观察丹红化瘀口服液、胰岛素及两者联合用药对糖尿病肾病大鼠的治疗效果。采用链脲佐菌素(STZ)诱导糖尿病肾病大鼠模型，STZ注射后1周后将造模成功的大鼠随机分为4组:糖尿病模型组、胰岛素组、丹红化瘀口服液组，丹红化瘀口服液联合胰岛素组，另设一正常组，每天给药1次，连续15周。丹红化瘀口服液联合胰岛素用药比两者单独用药能更显著降低空腹血糖、24 h饮水量、摄食量和尿量，降低血清尿素与尿素/肌酐比，改善肾脏肥大和肾组织病理损伤，同时提高血清Na+与Cl-水平。结果提示:丹红化瘀口服液可辅助胰岛素治疗糖尿病肾病。
    Abstract: Danhong Huayu Koufuye (DHK), a traditional Chinese prescription, has activities of promoting blood circulation to remove blood stasis and promoting qi circulation to remove meridian obstruction. The aim of the study was to investigate effects of DHK, insulin and their combination on diabetic nephropathy(DN)in streptozotocin(STZ, 50 mg/kg, ip)-induced diabetic Sprague-Dawley rats. Rats were divided into five groups: normal control, model control, insulin, DHK, and DHK plus insulin. The animals were treated once daily for 15 weeks starting one week after STZ injection. The combination of DHK with insulin resulted in more significant effects than insulin or DHK alone on decreasing fasting blood glucose, 24 h water intake, diet intake and urine volume, reducing serum urea level and urea-to-Cr ratio, promoting kidney hypertrophy and renal damage, and increasing serum Na+ and Cl- level as well. These results suggest that DHK may be a valuable adjuvant therapy for DN.
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    • 参考文献(14)
  • [1] Dalla Vestra M,Saller A,Bortoloso E,et al.Structural involvement in type 1 and type 2 diabetic nephropathy[J].Diabetes Metab,2000, 26(Suppl 4):8-14.
    [2] Yokoyama H,Okudaira M,Otani T,et al.Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan[J].Kidney Int,2000, 58(1):302-311.
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    [7] The Diabetes Control and Complications Trial/Epidemiology diabetes interventions and complications research group.Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy[J].N Engl J Med,2000, 342:381-389.
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    [12] Hartner A,Cordasic N,Klanke B,et al.Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension,not on diabetes[J].Am J Physiol Renal Physiol,2007, 292:F820-F827.
    [13] Hannedouche TP,Delgado AG,Gnoinsahe DA,et al.Renal hemodynamics and segmental tubular reabsorption in early type 1 diabetes[J].Kidney Int,1990, 37(4):1 126-1 133.
    [14] Salman IM,Ameer OZ,Sattar MA,et al.Characterization of renal hemodynamic and structural alterations in rat models of renal impairment:role of renal sympathoexcitation[J].J Nephrol,2011, 24(1):68-77.
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  • 刊出日期:  2013-12-24

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