• 中国中文核心期刊
  • 中国科学引文数据库核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
高级检索

超临界CO2抗溶剂法制备头孢呋辛酯微粒的工艺研究

周敦晖, 乐龙, 王志祥, 党蓓蕾, 颜庭轩, 黄德春

周敦晖, 乐龙, 王志祥, 党蓓蕾, 颜庭轩, 黄德春. 超临界CO2抗溶剂法制备头孢呋辛酯微粒的工艺研究[J]. 中国药科大学学报, 2013, 44(6): 596-599. DOI: 10.11665/j.issn.1000-5048.20130621
引用本文: 周敦晖, 乐龙, 王志祥, 党蓓蕾, 颜庭轩, 黄德春. 超临界CO2抗溶剂法制备头孢呋辛酯微粒的工艺研究[J]. 中国药科大学学报, 2013, 44(6): 596-599. DOI: 10.11665/j.issn.1000-5048.20130621
shu
ZHOU Dunhui, YUE Long, WANG Zhixiang, DANG Beilei, YAN Tingxuan, HUANG Dechun. Preparation of cefuroxime axetil particles by supercritical CO2 anti-solvent technology[J]. Journal of China Pharmaceutical University, 2013, 44(6): 596-599. DOI: 10.11665/j.issn.1000-5048.20130621
Citation: ZHOU Dunhui, YUE Long, WANG Zhixiang, DANG Beilei, YAN Tingxuan, HUANG Dechun. Preparation of cefuroxime axetil particles by supercritical CO2 anti-solvent technology[J]. Journal of China Pharmaceutical University, 2013, 44(6): 596-599. DOI: 10.11665/j.issn.1000-5048.20130621
shu

超临界CO2抗溶剂法制备头孢呋辛酯微粒的工艺研究

  • 中国药科大学制药工程教研室

基金项目: 江苏省自然科学基金资助项目(No.BK2012763)；中央高校基本科研业务费专项资金资助项目(No.JKY2011026)

Preparation of cefuroxime axetil particles by supercritical CO2 anti-solvent technology

摘要

    摘要
  • 摘要: 采用超临界CO2抗溶剂法制备头孢呋辛酯微粒，以体积平均粒径为主要评价指标，在单因素实验的基础上设计正交试验优选制备头孢呋辛酯微粒的工艺，并对优选工艺组合进行粒度分布、扫描电镜、红外吸收光谱法(IR)及差示扫描热量法(DSC)的表征。正交试验得到的优选工艺为:结晶压力10 MPa，结晶温度50 ℃，头孢呋辛酯质量浓度6 mg/mL。在此工艺下制得的微粒体积平均粒径为6.729 μm，IR与DSC分析表明头孢呋辛酯微粒的化学结构没有发生变化，热力学性质发生了变化，经过处理的头孢呋辛酯变为无定型。
    Abstract: Cefuroxime axetil micro particles were prepared by using supercritical CO2 anti-solvent technology. With volume average particle size as the main evaluation, on the basis of single factor experiments orthogonal experimental design was used to optimize the preparation process of cefuroxime axetil particles. The experiments such as particle size distribution, scanning electro microscope analysis(SEMA), infrared spectrum(IR)and differential scanning calorimetry(DSC)were used to analyze the particles. The orthogonal experimental optimization process conditions were set as follows: crystallization pressure 10 MPa, crystallization temperature 50 ℃ and mass concentration of cefuroxime axetil 6 mg/mL, Under the optimum conditions, the volume average particle size was 6. 729 μm, IR and DSC analysis showed that the chemical structure didn′t change but the thermodynamic properties of cefuroxime axetil might transfer transform to amorphous.
    • HTML全文
    • 参考文献(10)
  • [1] Cai JY,Huang DC,Wang ZX,et al.The application of supercritical anti-solvent technology in the field of microparticulate powder[J].Pharmacy Today(今日药学),2011,21(12):768-772.
    [2] Liu Q,Zhu MH,Zu YG,et al.Comparative antioxidant activity of nanoscale lignin prepared by a supercritical antisolvent(SAS)process with non-nanoscale lignin[J].Food Chem,2012,135(1):63-67.
    [3] Jin HY,Melinda H,Ram B G, et al.Preparation of thalidomide nano-flakes by supercritical antisolvent with enhanced mass transfer[J].Particuol,2012,10(1):17-23.
    [4] Huang J,Yan TX,Wang ZX,et al.Research on preparation of baicalein particles by supercritical CO2 anti-solvent technology[J].Chin Tradit Herbal Drugs(中草药),2013,44(8):970-973.
    [5] Montes A,Tenorio A,Gordillo MD, et al.Screening design of experiment applied to supercritical antisolvent precipitation of amoxicillin: exploring new miscible conditions[J].J Supercritical Fluids,2010, 51(3):399-403.
    [6] Zordi ND,Kikic I,Moneghini M,et al.Piroxicam solid state studies after processing with SAS technique[J].J Supercritical Fluids,2010, 55(1):340-347.
    [7] Zhang JL,Bai P.Research on synthesis of cefuroxime axetil[J].Hebei J Ind Sci Technol(河北工业科技),2006,23(6):328-329.
    [8] Wang JX, Zhang QX, Zhou Y, et al. Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate[J].Chem Engineering J,2010,162(2):844-851.
    [9] Zhang JY,Shen ZG,Zhong J, et al.Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants[J].Int J Pharm,2006,323(1/2):153-160.
    [10] Varshosaz J,Hassanzadeh F,Mahmoudzadeh M,et al.Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercri-tical fluid technology[J].Powder Technol,2009,189(1):97-102.
    • 相关文章
    • 施引文献
    • 资源附件(0)
计量
  • 文章访问数:  1257
  • HTML全文浏览量:  0
  • PDF下载量:  1999
  • 被引次数: 0
出版历程
  • 刊出日期:  2013-12-24

目录

摘要
HTML全文
    参考文献(10)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    版权所有：《中国药科大学学报》编辑部苏ICP备05007142号

    地址：江苏省南京市鼓楼区童家巷24号（210009）电话: 025-83271566E-mail: xuebao@cpu.edu.cn

    本系统由 北京仁和汇智信息技术有限公司 开发  百度统计

    访问量：335928

    x 关闭 永久关闭