Abstract: Lipoproteins which are endogenous, biocompatible, completely biodegradable, and non-immunogenic, and can escape recognition and elimination by the reticuloendothelial system(RES)may well be studied as drug carriers. This article summarizes the advances in lipoprotein(chylomicrons, very low-density lipoprotein, low-density lipoprotein and high-density lipoprotein)-based nano scale drug delivery systems(LNDDS)in recent years.