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复方熊去氧胆酸口服液对大鼠淤胆型肝炎的影响

尤梅桂, 陈同, 倪远宁, 季晖

尤梅桂, 陈同, 倪远宁, 季晖. 复方熊去氧胆酸口服液对大鼠淤胆型肝炎的影响[J]. 中国药科大学学报, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
引用本文: 尤梅桂, 陈同, 倪远宁, 季晖. 复方熊去氧胆酸口服液对大鼠淤胆型肝炎的影响[J]. 中国药科大学学报, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
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YOU Meigui, CHEN Tong, NI Yuanning, JI hui. Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats[J]. Journal of China Pharmaceutical University, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
Citation: YOU Meigui, CHEN Tong, NI Yuanning, JI hui. Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats[J]. Journal of China Pharmaceutical University, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
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复方熊去氧胆酸口服液对大鼠淤胆型肝炎的影响

  • 中国药科大学药理学教研室

Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats

摘要

    摘要
  • 摘要: 观察复方熊去氧胆酸口服液(C-UDCA)对大鼠肝内胆汁淤积型肝炎的影响。采用灌胃α-萘异硫氰酸酯(ANIT)诱发大鼠淤胆型肝炎模型，检测经口给予C-UDCA后对大鼠胆汁流量、肝功能各项生化指标、肝组织生化指标及肝组织病理形态学的影响。结果显示，C-UDCA能明显减轻ANIT导致的胆管损伤、胆汁淤积和肝细胞损伤。与单方熊去氧胆酸(UDCA)比较，C-UDCA 高、中剂量组能显著降低血清丙氨酸转氨酶(ALT)水平、升高肝组织Na+-K+-ATPase、SOD酶活性。提示C-UDCA对ANIT诱导的急性肝内胆汁淤积型肝炎有明显的改善作用，且C-UDCA的作用优于UDCA。
    Abstract: The study was designed to investigate the effect of compound ursodeoxycholic acid oral liquid(C-UDCA)on acute intrahepatic cholestasis in rats, which was induced by α-naphthylisothiocyanate(ANIT, 150 mg/kg). The effects of C-UDCA were examined by serological determination, histological assessment of liver damage and bile excretion experiments. Results demonstrated that the administration of C-UDCA could significantly ameliorate ANIT-induced bile duct injury, cholestasis and hepatocytic damage. Compared with ursodeoxycholic acid(UDCA), high and mediumdoses of C-UDCA could remarkably reduce the elevated serum levels of alanine aminotransferase(ALT), while greatly enhancing the activity of Na+-K+-ATPase and SOD in liver tissues. All taken together, our data suggested that C-UDCA exhibited a better hepatoprotective effect against ANIT-induced cholestasis than UDCA.
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    • 参考文献(9)
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    [7] Xu XW,Li LJ,Lu FF,et al.Ursodeoxycholic acid therapy in rats with intrahepatic cholestasis[J].Chin J Hepatol(中国肝脏病杂志),2003,11(3):244-245.
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  • 刊出日期:  2014-02-24

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