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叶酸修饰的介孔氧化硅纳米粒制备及其负载雄黄研究

沈玲玲, 陈金龙, 苏梦翔, 严方, 李博, 狄斌

沈玲玲, 陈金龙, 苏梦翔, 严方, 李博, 狄斌. 叶酸修饰的介孔氧化硅纳米粒制备及其负载雄黄研究[J]. 中国药科大学学报, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311
引用本文: 沈玲玲, 陈金龙, 苏梦翔, 严方, 李博, 狄斌. 叶酸修饰的介孔氧化硅纳米粒制备及其负载雄黄研究[J]. 中国药科大学学报, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311
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SHEN Lingling, CHEN Jinlong, SU Mengxiang, YAN Fang, LI Bo, DI Bin. Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar[J]. Journal of China Pharmaceutical University, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311
Citation: SHEN Lingling, CHEN Jinlong, SU Mengxiang, YAN Fang, LI Bo, DI Bin. Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar[J]. Journal of China Pharmaceutical University, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311
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叶酸修饰的介孔氧化硅纳米粒制备及其负载雄黄研究

  • 1.

    中国药科大学药物分析教研室

  • 2.

    中国药科大学教育部药物质量与安全预警重点实验室

基金项目: 新疆维吾尔自治区自然科学基金资助项目(No.201233146-7)

Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar

摘要

    摘要
  • 摘要: 以正硅酸四乙酯(TEOS)为硅源，十六烷基三甲基溴化铵(CTAB)为模板剂，乙醇为助溶剂，三乙醇胺为螯合剂在碱性条件下合成了介孔氧化硅纳米粒(MSN)，然后在其表面通过后嫁接法键合氨丙基，再修饰叶酸(FA)，对其形貌和结构进行表征，利用原子荧光光谱仪测定其对雄黄的负载率。结果表明，MSN具有大的比表面积(973 m2/g)和孔体积(1.01 cm3/g)、孔径分布窄、粒径均匀(90 nm左右)且球形形貌分散，修饰FA后的介孔氧化硅纳米粒(MSN-NH-FA)在0.5 h 对雄黄的负载率最大，达到2.52%。结果表明，制备的MSN-NH-FA具有较好的形貌结构，适合作为药物载体，具有良好的应用前景。
    Abstract: Mesoporous silica nanoparticles(MSN)were synthesized under alkaline conditions using tetraethoxysilane(TEOS)as silica source, hexadecyl trimethyl ammonium bromide(CTAB)as template agent, ethanol as co-solvent and triethanolamine as chelating agent. Ammonia propyl and folic acid(FA)were then modified on the surface of MSN in two consecutive steps. The morphology and structure were characterized, and the loading amount of realgar was determined by atomic fluorescence spectrometry. Results showed that the MSN had large specific surface area(973 m2/g)and pore volume(1. 01 cm3/g), narrow pore size distribution, uniform particle size(about 90 nm)and well-dispersed spherical morphology. The assayed loading ratio of realgar in FA- modified MSN reached the maximum(2. 52%)in 0. 5 h. Hence, it was shown that the MSN-NH-FA has good morphology and favorable structure which is suitable as a drug carrier and hold potential in the application.
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    • 参考文献(13)
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  • 刊出日期:  2014-06-24

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