Abstract:
Novel hybrid compounds
7a-7p were designed and synthesized via conjugating farnesylthiosalicylic acid(FTS)and hydroxylcinnamic acids, and their
in vitro biological activities were evaluated. It was found that most compounds displayed good to moderate
in vitro antitumor activities against six human cancer cells. Especially, the antitumor activities of compound
7b , with the IC
50 values of 5. 51-9. 25 μmol/L range against all tested cancer cells, were superior to those of FTS and sorafenib, and compound
7b could selectively inhibit the proliferation of tumor cells but not that of human normal cell. Furthermore, compound
7b significantly induced SMMC-7721 cell apoptosis in a dose-dependent manner.