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肿瘤CD44受体靶向及pH敏感寡聚透明质酸-缩酮载体的制备及表征

连胜男, 孙京芳, 孙考祥, 刘万卉, 陈大全

连胜男, 孙京芳, 孙考祥, 刘万卉, 陈大全. 肿瘤CD44受体靶向及pH敏感寡聚透明质酸-缩酮载体的制备及表征[J]. 中国药科大学学报, 2014, 45(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20140506
引用本文: 连胜男, 孙京芳, 孙考祥, 刘万卉, 陈大全. 肿瘤CD44受体靶向及pH敏感寡聚透明质酸-缩酮载体的制备及表征[J]. 中国药科大学学报, 2014, 45(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20140506
LIAN Shengnan, SUN Jingfang, SUN Kaoxiang, LIU Wanhui, CHEN Daquan. Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier[J]. Journal of China Pharmaceutical University, 2014, 45(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20140506
Citation: LIAN Shengnan, SUN Jingfang, SUN Kaoxiang, LIU Wanhui, CHEN Daquan. Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier[J]. Journal of China Pharmaceutical University, 2014, 45(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20140506

肿瘤CD44受体靶向及pH敏感寡聚透明质酸-缩酮载体的制备及表征

基金项目: 国家自然科学基金资助项目(No.81302718);烟台大学研究生科技创新基金资助项目(No.YJSY201425)

Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier

  • 摘要: 利用组氨酸将母体材料寡聚透明质酸和pH敏感材料薄荷缩酮连接,制备了具有pH敏感和CD44受体靶向的寡聚透明质酸-缩酮载体,用1H NMR和ESI-MS进行结构表征,并初步考察了寡聚透明质酸-缩酮载体材料胶束的制备、电镜形貌特征及pH敏感特性。结果表明,合成了两亲性的寡聚透明质酸-缩酮载体,在水中可自组装形成胶束,电镜形态为类球形,粒径100 nm左右,并且具有一定pH敏感性。因此,寡聚透明质酸-缩酮可作为新型CD44受体及pH敏感肿瘤靶向载体。
    Abstract: Oligomeric hyaluronic acid(oHA)and ketal was linked by histidine to form a novel oHA-ketal(oHM)carrier with targeting capacity to CD44 receptor and pH sensitivity. The chemical structure of oHM was characterized by 1H NMR and ESI-MS. Some properties, including the formation of micelles, morphology and pH-sensitivity were studied. The oHM can form micelles by self-assembly. The micelles were spherical shape with the diameter about 100 nm, and they also showed some pH-sensitivity. Therefore, oHM could be a potential pH-sensitive tumor targeting carrier to CD44 receptor.
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出版历程
  • 刊出日期:  2014-10-24

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