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短葶山麦冬皂苷DT-13研究进展

Advances in the research on DT-13, a saponin of Liriope muscari(Decne)Baily

  • 摘要: 短葶山麦冬[Liriope muscari (Decne)Baily]为山麦冬的基原植物之一。短葶山麦冬皂苷DT-13为其主要的活性成分,具有抗肿瘤转移、增强免疫、抗炎等多种药理活性。本文对短葶山麦冬皂苷DT-13的化学结构、提取分离、含量测定、药理活性和安全性评价等进行综述,进一步阐明短葶山麦冬皂苷DT-13的研究价值和应用前景。

     

    Abstract: Liriope Muscari [Liriope Muscari(Decne)Baily], one of the original plant-loading varieties of Radix Liriopes included in “China Pharmacopoeia”(2010 ed), has various effects such as nourishing yin and promoting the secretion of body fluid, moistening lung and clearing away the heart-fire with the dried root. The saponin, DT-13, is the major active constituent of Liriope tuberous root, with a variety of pharmacological activities including anti-tumor metastasis, enhancing immunity, and anti-inflammation. In this paper, the chemical structure, content determination, pharmacological activities and safety evaluation of DT-13 were summarized. It suggests that DT-13 could be considered as a candidate drug with important research potentials and various promising application.

     

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