Abstract: With their antitumor advantages, paclitaxel nanoliposomes have been widely used in clinical treatment. Numerous works on paclitaxel nanoliposomes have been studied and have made great progress. This paper discusses the ways to improve the solubility of paclitaxel, to improve the targeting of nanoliposomes, and to optimize its preparation conditions, with also a prospect of the future development of paclitaxel nanoliposomes.