Abstract: Osmotic pump drug delivery system(OPDDS)can obtain an extended drug release at zero-order rate. The release condition is not influenced by the gastric pH and hydrodynamic conditions of the body and exhibits good in vitro-in vivo correlation. Additionally, it can significantly reduce drug administration to one time a day and decrease the fluctuation of drug concentration in plasma, achieving better patient compliance and adherence. Besides, it can improve the therapeutic efficiency of drugs with short biological half-lives, reducing or eliminating the side-effects. Therefore, the OPDDS is a focus of pharmaceutics research. In this article, new progresses in the research of osmotic pump preparations, such as micro-porous osmotic pump drug delivery system, sandwiched osmotic pump drug delivery system, gastric-resident osmotic pump drug delivery system, subcutaneous osmotic pump drug delivery system, are reviewed for the pharmaceutical researchers to design and develop new osmotic pump delivery systems.