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小酸浆中Withaphysalins的分离和结构鉴定

周咏梅, 石贤明, 马磊, 张思访

周咏梅, 石贤明, 马磊, 张思访. 小酸浆中Withaphysalins的分离和结构鉴定[J]. 中国药科大学学报, 2015, 46(1): 62-65. DOI: 10.11665/j.issn.1000-5048.20150107
引用本文: 周咏梅, 石贤明, 马磊, 张思访. 小酸浆中Withaphysalins的分离和结构鉴定[J]. 中国药科大学学报, 2015, 46(1): 62-65. DOI: 10.11665/j.issn.1000-5048.20150107
shu
ZHOU Yongmei, SHI Xianming, MA Lei, ZHANG Sifang. Isolation and identification of Withaphysalins from Physalis minima[J]. Journal of China Pharmaceutical University, 2015, 46(1): 62-65. DOI: 10.11665/j.issn.1000-5048.20150107
Citation: ZHOU Yongmei, SHI Xianming, MA Lei, ZHANG Sifang. Isolation and identification of Withaphysalins from Physalis minima[J]. Journal of China Pharmaceutical University, 2015, 46(1): 62-65. DOI: 10.11665/j.issn.1000-5048.20150107
shu

小酸浆中Withaphysalins的分离和结构鉴定

  • 1.

    江苏建康职业学院

  • 2.

    华东理工大学药学院

基金项目: 江苏省卫生职业技术教育研究课题资助项目(No.JZ201006)

Isolation and identification of Withaphysalins from Physalis minima

摘要

    摘要
  • 摘要: 研究小酸浆Physalis minima L.的活性成分。小酸浆的地上部分经乙醇提取，氯仿萃取，D-101大孔树脂柱色谱粗分，Sephadex LH-20、MCI gel CHP 20P、RP-18等色谱柱分离，并通过理化常数和波谱学方法鉴定化合物结构。从小酸浆中分离鉴定了5个化合物，分别为Withaphysalin P(Ⅰ)、14，18-di-O-acetylwithaphysalin C(Ⅱ)、Withaphysalin Q(Ⅲ)、Withaphysalin型化合物 1 (Ⅳ)、Withaphysalin型化合物 2 (Ⅴ)。化合物Ⅳ、Ⅴ为新化合物，分别命名为Withaphysalin T、Withaphysalin U。
    Abstract: To investigate the chemical constituents of Physalis minima L. , compounds were isolated by chromatographic methods from Physalis minima L. . Their structures were determined on the basis of spectral analysis. Five compounds were isolated and identified as Withaphysalin P(I), 14, 18-di-O-acetylwithaphysalin C(II), Withaphysalin Q(III), Withaphysalin 1 (IV)and Withaphysalin 2 (V). Compounds IV and V are new compounds, orderly named as Withaphysalin T and Withaphysalin U.
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  • [1] Sathis KD,Raju SN,Harani A,et al.Alpha-glucosidase inhibitory and hypoglycemic activities of Physalis minima extract[J].Pharmacogn J,2009,1(4):273-278.
    [2] Choudhary MI,Yousuf S,Samreen,et al.New leishmanicidal physalins from Physalis minima[J].Nat Prod Res,2007,21(10):877-883.
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    [5] Ma L,Gan XW,He QP,et al.Cytotoxic withaphysalin from Physalis minima[J].Helvetica Chimica Acta,2007,90:1406-1419.
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    [7] Shariff N,Sudarshana MS,Umesha S,et al.Antimicrobial activity of Rauvolfia tetraphylla and Physalis minima leaf and callus extracts[J].Afr J Biotechnol,2006,5(10):946-950.
    [8] Patel T,Shah K,Jiwan K,et al.Study on the antibacterial potential of Physalis minima Linn[J].Indian J Pharm Sci,2011,73(1):111-115.
    [9] Sahai M,Kirson I.Withaphysalin D,a new withaphysalin from Physalis minima Linn.var.indica[J].J Nat Prod,1984,47:527-529.
    [10] Yoshiteru O,Anjana B,Hiroshi H.Withaphysalin E,a withanolide of Physalis minima var.Indica[J].Phytochemistry,1987,26(7):2115-2117.
    [11] Editorial Committee of Chinese Materia Medica.Chinese Materia Medica(中华本草)(Volume Ⅶ)[M].Shanghai:Shanghai Science and Technology Press,1999,7:292.
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  • 刊出日期:  2015-02-24

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