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自组装多肽在生物医药领域的研究进展

张晨羽, 李雪, 钱海, 黄文龙

张晨羽, 李雪, 钱海, 黄文龙. 自组装多肽在生物医药领域的研究进展[J]. 中国药科大学学报, 2015, 46(2): 250-256. DOI: 10.11665/j.issn.1000-5048.20150219
引用本文: 张晨羽, 李雪, 钱海, 黄文龙. 自组装多肽在生物医药领域的研究进展[J]. 中国药科大学学报, 2015, 46(2): 250-256. DOI: 10.11665/j.issn.1000-5048.20150219
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ZHANG Chenyu, LI Xue, QIAN Hai, HUANG Wenlong. Self-assembled peptide:insights and biomedicine applications[J]. Journal of China Pharmaceutical University, 2015, 46(2): 250-256. DOI: 10.11665/j.issn.1000-5048.20150219
Citation: ZHANG Chenyu, LI Xue, QIAN Hai, HUANG Wenlong. Self-assembled peptide:insights and biomedicine applications[J]. Journal of China Pharmaceutical University, 2015, 46(2): 250-256. DOI: 10.11665/j.issn.1000-5048.20150219
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自组装多肽在生物医药领域的研究进展

  • 中国药科大学新药研究中心

基金项目: 国家自然科学基金资助项目(No.81172932,No.81273376)

Self-assembled peptide:insights and biomedicine applications

摘要

    摘要
  • 摘要: 自组装多肽可利用分子间非共价键作用力自发或触发自组装，形成有序的纳米结构，表现出单个多肽分子或低级分子聚集体所没有的独特特性与功能，近年来该领域已成为分子自组装研究的热点之一。根据自组装是否受外界环境的调控将其分为自发型和触发型两种类型，详细介绍了自组装多肽的分类以及其在生物医药领域中的应用前景，包括作为抗肿瘤药物及抗生素药物；作为药物载体改善药物的性质，实现药物靶向性；以及在细胞培养支架、组织修复、生物医学检测等方面的应用。
    Abstract: Self-assembled peptides occur via inter-molecular non-covalent assembly, spontaneity or triggering, and the formed nanostructures have been found to have certain features and functions which are not shown by the original peptide molecules or low-hierarchical molecules. There are growing attentions on the self-assembled peptide. This review provides detailed classifications of self-assembled peptides, i. e. , spontaneity and triggering, according to how the self-assemble responds or adjusts to outer environment. In addition, the summary offers potentials of their applications in biomedicine, such as anti-tumor and anti-bacterial medicine, drug carriers modifying pharmaceutical features of drugs, enhanced drug targeting, matrix as cell culture, tissue regeneration, and biomedicinal detection.
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  • 刊出日期:  2015-04-24

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