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共无定形辛伐他汀-格列齐特的理化性质

陈娟, 郭慧慧, 张建军, 高缘

陈娟, 郭慧慧, 张建军, 高缘. 共无定形辛伐他汀-格列齐特的理化性质[J]. 中国药科大学学报, 2015, 46(3): 301-308. DOI: 10.11665/j.issn.1000-5048.20150307
引用本文: 陈娟, 郭慧慧, 张建军, 高缘. 共无定形辛伐他汀-格列齐特的理化性质[J]. 中国药科大学学报, 2015, 46(3): 301-308. DOI: 10.11665/j.issn.1000-5048.20150307
CHEN Juan, GUO Huihui, ZHANG Jianjun, GAO Yuan. Physicochemical characteristics of coamorphous simvastatin-gliclazide[J]. Journal of China Pharmaceutical University, 2015, 46(3): 301-308. DOI: 10.11665/j.issn.1000-5048.20150307
Citation: CHEN Juan, GUO Huihui, ZHANG Jianjun, GAO Yuan. Physicochemical characteristics of coamorphous simvastatin-gliclazide[J]. Journal of China Pharmaceutical University, 2015, 46(3): 301-308. DOI: 10.11665/j.issn.1000-5048.20150307

共无定形辛伐他汀-格列齐特的理化性质

基金项目: 江苏省自然科学基金资助项目(No.BK20141351);江苏高校优势学科建设工程资助项目(PAPD);江苏省高校“青蓝工程”资助项目

Physicochemical characteristics of coamorphous simvastatin-gliclazide

  • 摘要: 制备共无定形辛伐他汀-格列齐特,对其溶出特性和物理稳定性进行了考察。结果证实产物为单相无定形态,辛伐他汀可能通过O-H与格列齐特磺酰脲基的C=O产生氢键相互作用,使通过常规方法难以制备成无定形的格列齐特实现了无定形化。共无定形物的形成显著提高了格列齐特的溶解度和溶出度,但对辛伐他汀无明显影响。与无定形辛伐他汀相比,该共无定形物的物理稳定性显著提高。
    Abstract: In this study, coamorphous simvastatin-gliclazide was prepared and characterized. Its single-phase amorphous nature was demonstrated. The hydrogen bond between the O-H group of simvastatin and sulfonylurea C=O group of gliclazide was revealed to be the trigger for the amorphization of gliclazide, which is difficult to form an amorphous state in other methods. Coamorphous simvastatin-gliclazide can significantly enhance the solubility and dissolution of gliclazide, without obvious effect on simvastatin. Compared with amorphous simvastatin, coamorphous simvastatin-gliclazide showed improved physical stability in the cunrent study.
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出版历程
  • 刊出日期:  2015-06-24

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