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Moesin蛋白在肿瘤进展中的作用

张婧晖, 王亚菁, 胡容

张婧晖, 王亚菁, 胡容. Moesin蛋白在肿瘤进展中的作用[J]. 中国药科大学学报, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319
引用本文: 张婧晖, 王亚菁, 胡容. Moesin蛋白在肿瘤进展中的作用[J]. 中国药科大学学报, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319
ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319
Citation: ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319

Moesin蛋白在肿瘤进展中的作用

基金项目: 国家自然科学基金资助项目(No.81202611)

Roles of Moesin in tumor progression

  • 摘要: Moesin是ERM(Ezrin/Radixin/Moesin)家族蛋白的成员之一。它是细胞膜与细胞骨架的连接蛋白,能够稳定细胞膜结构,参与调控细胞形态的改变,并且通过调节细胞信号转导参与细胞迁移、黏附和极化过程。Moesin与肿瘤的发生、发展过程紧密相关,它通过细胞骨架和细胞信号转导,在肿瘤进程的多个环节起到至关重要的作用。本文综述了在临床样本中,Moesin及其磷酸化形式的表达水平与肿瘤恶性程度、转移和预后的关系。深入阐述了Moesin促进肿瘤侵袭转移、EMT过程和肿瘤细胞增殖的分子机制,并且总结了以Moesin为靶点的药物研发进展。
    Abstract: Moesin is a component of ERM(Ezrin/Radixin/Moesin)family proteins linking cell membrane proteins with cytoskeleton. It is involved in cell morphological change and the maintaining of cell cortex and is also involved in cell adhesion, migration and polarization by regulating the signal transduction pathways. Moesin plays a vital role in several aspects of tumor initiation and progression through its regulation on cytoskeleton and signal transduction pathways. This article reviews the close relation between Moesin and its phosphorylated form with the higher level of malignancy and poor prognosis through clinic data analysis. Furthermore, the role and mechanism of Moesin on tumor migration, EMT and tumor proliferation are presented. Drug research and development based on the target of Moesin are also concluded.
  • [1] Sato N,Funayama N,Nagafuchi A,et al.A gene family consisting of ezrin,radixin and moesin.Its specific localization at actin filament/plasma membrane association sites[J].J Cell Sci,1992,103(1):131-143.
    [2] Bretscher A,Edwards K,Fehon RG.ERM proteins and merlin:integrators at the cell cortex[J].Nat Rev Mol Cell Biol,2002,3(8):586-599.
    [3] Fehon RG,Mcclatchey AI,Bretscher A.Organizing the cell cortex:the role of ERM proteins[J].Nat Rev Mol Cell Biol,2010,11(4):276-287.
    [4] Lan M, Kojima T, Murata M, et al. Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line[J].Exp Cell Res,2006,312(2):111-120.
    [5] Baumgartner M, Sillman AL, Blackwood EM, et al. The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors[J].Proc Natl Acad Sci U S A,2006,103(36):13391-13396.
    [6] Takeuchi K,Sato N,Kasahara H,et al.Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members[J].J Cell Biol,1994,125(6):1371-1384.
    [7] Neisch AL,Fehon RG.Ezrin,radixin and moesin:key regulators of membrane-cortex interactions and signaling[J].Curr Opin Cell Biol,2011,23(4):377-382.
    [8] Jung Y,Mccarty JH.Band 4.1 proteins regulate integrin-dependent cell spreading[J].Biochem Biophys Res Commun,2012,426(4):578-584.
    [9] Lin L. Studies on expressions of Ezrin and Moesin in cervical squamous cell carcinoma and Siha cell(Ezrin和Moesin在宫颈鳞癌组织和SiHa细胞表达的研究)[D].Fuzhou:Fujian Mdeical University,2008.
    [10] Zhou Q,Deng T.Expression of Moesin and Endogolin(CD105)in squamous carcinoma and its clinic significance[J].J Prac Obst Gyne(实用妇产科杂志),2011,27(2):106-109.
    [11] Wu M.Expressiong and significance of Moesin in human brain astrocytoma,and its influence on growth and invasion of U251 cell(Moesin在人脑星形细胞瘤中的表达和意义及其对U251细胞增殖和侵袭的影响)[D].Changsha:Zhongnan University,2010.
    [12] Zhu X,Morales FC,Agarwal NK,et al.Moesin is a glioma progression marker that induces proliferation and Wnt/beta-catenin pathway activation via interaction with CD44[J].Cancer Res,2013,73(3):1142-1155.
    [13] Liu C,Tao XF,Gao ZN,et al.Corrlation of Moesin and E-cadherin with invasion of papillary thyroid carcinoma[J].Canc Res Prev & Treat(肿瘤防治研究),2012,39(1):44-47.
    [14] Zhang LP,Pu HW,Chen X,et al.Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma[J].J Cap Med Univ(首都医科大学学报),2012,33(5):575-580.
    [15] Desouza LV,Matta A,karim Z,et al.Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme[J].Mol Cancer,2013,12(74):1-13.
    [16] Kahsai AW,Zhu S,Wardrop DJ,et al.Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin,disrupting interactions of radixin with actin and CD44[J].Chem Biol,2006,13(9):973-983.
    [17] Giretti MS,Monttguevara MM,Cecchi E,et al.Effects of estetrol on migration and invasion in T47-D breast cancer cells through the actin cytoskeleton[J].Front Endocrinol,2014,5(80):1-8.
    [18] Wang CC,Liau JY,Lu YS,et al.Differential expression of moesin in breast cancers and its implication in epithelial-mesenchymal transition[J].Histopathology,2012,61(1):78-87.
    [19] Abiatari I, Esposito I, Oliveira TD, et al. Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer[J].J Cell Mol Med,2010,14(5):1166-1179.
    [20] Haynes J,Srivastava J,Madson N,et al.Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression[J].Mol Biol Cell,2011,22(24):4750-4764.
    [21] Chiang CD,Kanzawa F,Matsushima Y,et al.Antitumor activity of quinocarmycin against carcinoma of the lung in human tumor clonogenic assay[J].J Pharmacobiodyn,1987,10(9):431-435.
    [22] Fujimoto K,Oka T,Morimoto M.Antitumor activity of a novel antitumor antibiotic,quinocarmycin citrate(KW2152)[J].Cancer Res,1987,47(6):1516-1522.
    [23] Plowman J,Dykes DJ,Narayanan VL,et al.Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice[J].Cancer Res,1995,55(4):862-867.
    [24] Saito H,Hirata T,Kasai M,et al.Synthesis and biological evaluation of quinocarcin derivatives:thioalkyl-substituted quinones and hydroquinones[J].J Med Chem,1991,34(7):1959-1966.
    [25] Saito H,Kobayashi S,Uosaki Y,et al.Synthesis and biological evaluation of quinocarcin derivatives[J].Chem Pharm Bull,1990,38(5):1278-1285.
    [26] Mirsalis JC,Schindler HJ,Hill JR,et al.Toxicity of a quinocarmycin analog,DX-52-1,in rats and dogs in relation to clinical outcome[J].Cancer Chemother Pharmacol,2003,51(3):193-201.
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  • 刊出日期:  2015-06-24

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