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水飞蓟素新型纳米制剂的研究进展

Advances in the nanotechnology-based drug delivery systems of silymarin

  • 摘要: 综述近年来水飞蓟素新型纳米制剂的研究进展。目前纳米传递系统可通过增加水飞蓟素的溶出速率(如:纳米混悬液、β-环糊精包合物、自乳化药物传递系统、固体分散体和微粉化技术)、提高生物膜的通透性(如:磷脂复合物、纳米结构脂质载体)以及其他方式(如:胶束、介孔二氧化硅纳米粒、聚酰胺-胺型树枝状高聚物)等,促进水飞蓟素的吸收、提高其生物利用度。对提高难溶性药物的生物利用度具有一定的指导意义。

     

    Abstract: Recent advances in nanotechnology have greatly facilitated the development of nanoparticle drug delivery system. The present work reviews recent literature on nanotechnology-based applications and developments of silymarin preparation. A variety of nanoparticle formulations have been extensively investigated to improve the absorption and bioavalability of silymarin, including: improving the drug dissolution signficantly(such as nanosuspensions, inclusion complex with β-cyclodextrins, self-emulsifying drug delivery systems, solid dispersions, micronization), promoting the permeability across cell membrane(such as complexation with phospholipids, nanostructured lipid carriers)and other methods(such as micelles, mesoporous silica nanoparticles, polyamidoamine dendrimers). The applications of nanoscience and nanotechnology can help to promote the further pharmaceutical development of silymarin.

     

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