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柳叶白前中非C21甾体类化学成分

Non-C21 steroids from the Rhizome of Cynanchum stauntonii

  • 摘要: 采用硅胶、凝胶及反相柱色谱等技术,对鹅绒藤属植物柳叶白前Cynanchum stauntonii干燥根茎80%乙醇提取物乙酸乙酯部位的非C21甾体类成分进行分离,得到12个化合物,利用波谱学方法和理化性质鉴定它们的结构为:丁香脂素( 1 )、(-)-(7R,7′R,7″R,8S,8′S,8″S)-4′,4″-二羟基-3,3′,3″,5-甲氧基-7,9′∶7′,9-环氧-4,8″-O-8,8′-倍半木质素-7″,9″-二醇( 2 )、8,8′-二羟基松脂素( 3 )、对羟基苯乙酮( 4 )、白首乌二苯酮( 5 )、2,4-二羟基苯乙酮( 6 )、苯甲酸( 7 )、对羟基苯酚( 8 )、6-O-[E]-芥子酰-α-D-吡喃葡萄糖苷( 9a )、6-O-[E]-芥子酰-β-D-吡喃葡萄糖苷( 9b )、1-O-甲基-α-D-吡喃加拿大麻糖甲苷( 10 )、β-胡萝卜苷( 11 )、β-谷甾醇( 12 )。其中化合物 1 ~ 357 ~ 11 为首次从该植物中分离得到。

     

    Abstract: Twelve compounds were isolated and purified from ethyl acetatefraction of Cynanchum stauntonii by silica gel, Sephadex LH-20 and ODS column chromatography. Their structures were identified by spectral techniques and physicochemical properties as syringaresinol( 1 ), (-)-(7R, 7′R, 7″R, 8S, 8′S, 8″S)-4′, 4″-dihydroxy-3, 3′, 3″, 5-tetramethoxy-7, 9′ ∶7′, 9-diepoxy-4, 8″-oxy-8, 8′-sesquineolignan-7″, 9″-diol( 2 ), prinsepiol( 3 ), 4-hydroxyacetophenone( 4 ), baishouwubenzophenone( 5 ), 2, 4-dihydroxyacetophenone( 6 ), benzoic acid( 7 ), 1, 4-benzenediol( 8 ), 6-O-[E]-sinapoyl-α-D-glucopyranoside( 9a ), 6-O-[E]-sinapoyl-β-D-glucopyranoside( 9b ), 1-O-methyl-α-D-cymadropyranoside( 10 ), β-daucosterol( 11 ), and β-sitosterol( 12 ). Compounds 1 - 3 , 5 and 7 - 11 were firstly isolated from this plant.

     

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