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多肽mPEG-SC20k-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用

何俊劲, 王佳艺, 郝静超, 程昊冉, 徐寒梅

何俊劲, 王佳艺, 郝静超, 程昊冉, 徐寒梅. 多肽mPEG-SC20k-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用[J]. 中国药科大学学报, 2015, 46(4): 476-480. DOI: 10.11665/j.issn.1000-5048.20150415
引用本文: 何俊劲, 王佳艺, 郝静超, 程昊冉, 徐寒梅. 多肽mPEG-SC20k-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用[J]. 中国药科大学学报, 2015, 46(4): 476-480. DOI: 10.11665/j.issn.1000-5048.20150415
HE Junjin, WANG Jiayi, HAO Jingchao, CHENG Haoran, XU Hanmei. Antitumor effect of peptide mPEG-SC20k-HM-3 and oxaliplatin combination against human hepatocellular carcinoma SMMC-7721 in nude mice[J]. Journal of China Pharmaceutical University, 2015, 46(4): 476-480. DOI: 10.11665/j.issn.1000-5048.20150415
Citation: HE Junjin, WANG Jiayi, HAO Jingchao, CHENG Haoran, XU Hanmei. Antitumor effect of peptide mPEG-SC20k-HM-3 and oxaliplatin combination against human hepatocellular carcinoma SMMC-7721 in nude mice[J]. Journal of China Pharmaceutical University, 2015, 46(4): 476-480. DOI: 10.11665/j.issn.1000-5048.20150415

多肽mPEG-SC20k-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用

基金项目: 国家高技术研究发展计划(863计划)资助项目(No.2012AA020304);国家“重大新药创制”科技重大专项资助项目(No.2014ZX09508007-001,No.2012ZX09103301-004)

Antitumor effect of peptide mPEG-SC20k-HM-3 and oxaliplatin combination against human hepatocellular carcinoma SMMC-7721 in nude mice

  • 摘要: mPEG-SC20k-HM-3是具有整合素亲和性的一种新型高效血管生成抑制多肽,为探索其与传统化疗药物联用的抗肿瘤活性,建立人肝癌细胞SMMC-7721裸鼠移植瘤模型,选用奥沙利铂为化疗药物,根据临床前抗肿瘤药效学方法评价联合用药的抑瘤作用,并用金氏公式判断两种药物的联合作用。结果显示,与单独用药相比,联合用药组的抑瘤效果更好,且均具有显著差异(P<;0.05)。其中,奥沙利铂(7.5 mg/kg)联合mPEG-SC20k-HM-3(73.4 mg/kg)的肿瘤抑制率为84.6%,抑制作用比单用奥沙利铂(7.5 mg/kg)和单用mPEG-SC20k-HM-3(73.4 mg/kg)均有显著提高。根据金氏公式计算,其Q值为1.164(>;1.15),可判定该组的用药组合表现出协同作用。结果表明,mPEG-SC20k-HM-3与奥沙利铂单独给药均能抑制肿瘤生长,两者联用对肝细胞癌具有协同作用。
    Abstract: mPEG-SC20k-HM-3 is a novel anti-angiogenesis peptide with integrin affinity. To investigate the anti-tumor activities of mPEG-SC20k-HM-3 and oxaliplatin(OXA)combination, a transplanted tumor model of human hepatocellular carcinoma SMMC-7721 in nude mice was established. Jin′s formula to evaluate the combination effect was used. Data suggested that the anti-tumor activities of combined groups were better than those of single drug(P< 0. 05). Inhibition rate of group 8(OXA 7. 5 mg/kg and mPEG-SC20k-HM-3 73. 4 mg/kg)was 84. 6%, which showed remarkable superiority to group 3(OXA 7. 5 mg/kg)and group 4(mPEG-SC20k-HM-3 73. 4 mg/kg). The Q of group 8 was 1. 164(> 1. 15). This combination had synergistic effect. Combination of mPEG-SC20k-HM-3 and oxaliplatin is a method of inhibiting hepatocellular carcinoma.
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  • 刊出日期:  2015-08-24

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