药物共晶技术中国专利申请状况分析
Patent analysis of pharmaceutical cocrystals technology in China
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摘要: 药物共晶是药物活性成分和共晶形成物以氢键或其他非共价键结合形成的晶体,近年来有关药物共晶的研究已成为药物研发的新热点。本文从专利申请状况、专利申请人、专利申请的法律状态、专利申请的技术等角度进行分析,为药物共晶研究提供研究方向。Abstract: Pharmaceutical cocrystals are formed from the active pharmaceutical ingredients and cocrystal formers through hydrogen bonding or other noncovalent bonds, which have attracted much attention in pharmaceutical field in recent years. From the analysis of patent application situation, patent applicant, legal status, and patent application techniques, guiding directions for the future research and development of the pharmaceutical cocrystals are proposed in this article.
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Keywords:
- pharmaceutical cocrystals /
- patent /
- empirical analysis /
- suggestion /
- iloperidone
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[1] Aakeröy CB,Debra J.Building co-crystals with molecular sense and supramolecular sensibility[J].Cryst Eng Comm,2005, 7(72):439-448. [2] Basavoju S,Boström D,Velaga SP.Pharmaceutical cocrystal and salts of norfloxacin[J].Cryst Growth Des,2006,6:2699-2708. [3] Liu YH,Shang ZH,Zhao XD,et al.Structure elucidation of Iloperdone by NMR spectra[J].J Hebei Normal Univ(河北师范大学学报),2012, 36(1):62-66.
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