Abstract: Drug delivery system targeting immune system plays an important role in the treatment of inflammatory diseases. Drug delivery system targeting immune system could target immune cells or immune organs. It could be divided into active targeting mediated by the interaction of ligand-receptor or antigen-antibody and passive targeting mediated by pH, particles and so on. This review summarizes new progress for drug delivery system targeting immune system, which provides a theoretical reference for designing the safe and effective drug delivery system and providing efficient and safe treatment for inflammatory diseases.