Abstract:
The aim of this study was to establish the methods to identify crystal form of dasatinib in tablets. X-ray powder diffraction(XRPD)and solid-state nuclear magnetic resonance(ssNMR)were used to analyze the crystal form of dasatinib in Sprycel
® tablets and Yinishu
® tablets. The results showed that monohydrate and anhydrate were identified in Sprycel
® and Yinishu
® tablets respectively, with no detectable anhydrate in Sprycel
® tablets and no detectable monohydrate in Yinishu
® tablets. The results of XRPD and ssNMR were consistent, and could be both applied in the crystal form identification of dasatinib in tablets.