Abstract: p75 neurotrophin receptor(p75NTR)is a low-affinity nerve growth factor receptor. It can interact with a variety of ligands and intracellular factors to play the prosurvival or proapoptoticrole in the nervous system. Besides, it plays an important role in apoptosis and nerve regeneration as a member of tumor necrosis factor receptor(TNFR)superfamily. More recently, a close relationship between p75NTR expression and pluripotency has been described. Thus, understanding the function of p75NTR has been challenging because it mediates many different cellular activities depending on the specific cell type and itsphysiological state. This review focuses on the expression of p75NTR and potential drug development targeting p75NTR.