[1] |
David LS,Frederick W,Tom WJ.Rheumatoid arthritis[J].Lancet,2010,376(6):1094-1108.
|
[2] |
Marije IK, Wim BV. Novel therapeutic targets in rheumatoid arthritis[J].Trends Pharmacol Sci,2015,36(4):1-7.
|
[3] |
Choy EH,Isenberg DA,Costenbader KH,et al.Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis:a randomized,double-blind,placebo-controlled,dose-escalation trial[J].Arthritis Rheum,2002,46(3):3143-3150.
|
[4] |
Karen EC,Agnes EC,Zhang ZG,et al.Changing glucocorticoid action:11β-hydroxysteroid dehydrogenase type1 in acute and chronic inflammation[J].J Steroid Biochem Mol Biol,2013,137(2):82-92.
|
[5] |
Brewer JA, Khor B, Beastall GH, et al. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation[J].Nat Med,2003,9(5):1318-1322.
|
[6] |
Bhattacharyya S,Brown DE,Spector TD,et al.Macrophage glucocorticoid receptors regulate Toll-like receptor-4-mediated inflammatory responses by selective inhibition of p38 MAP kinase[J].Blood,2007,109(2):4313-4319.
|
[7] |
Engdahl C,Jochems C,Alarcon GS,et al.Amelioration of collagen-induced arthritis and immune associated bone loss through signaling via estrogen receptor alpha,and not estrogen receptor beta or G protein-coupled receptor 30[J].Arthritis Rheum,2010,62(17):524-533.
|
[8] |
Mueck AO,Seeger H.2-Methoxyestradiol-biology and mechanism of action[J].Steroids,2010,75(10):625-631.
|
[9] |
Campo GM,Avenoso A,Campo S,et al.Chondroitin-4-sulphate inhibits NF-κB translocation and caspase activation in collagen-induced arthritis in mice[J].Osteoarthritis Cartilage,2008,16(12):1474-1483.
|
[10] |
Antero S,Jari H,Johanna O,et al.Activation of innate immunity system during aging:NF-κB signaling is the molecular culprit of inflamm-aging[J].Ageing Res Rev,2008,7(2):83-105.
|
[11] |
Jan X,Guang SF,Sha WC,et al.Methylprednisolone inhibition of TNF-α expression and NF-κB activation after spinal cord injury in rats[J].Mol Brain Res,1998,59(2):135-142.
|
[12] |
Turnbull AV,Rivier CL.Regulation of the hypothalamic-pituitary-adrenalaxis by cytokines:actions and mechanisms of action[J].Physiol Rev,1999,79(5):1-71.
|
[13] |
Funder JW.Mineralocorticoid receptor activation and oxidative stress[J].Hypertension,2007,50(2):840-841.
|
[14] |
Usher MG,Duan SZ,Brown S,et al.Myeloid mineralocorticoid receptor controlsmacrophage polarization and cardiovascular hypertrophy and remodeling inmice[J].J Clin Invest,2010,120(2):3350-3364.
|
[15] |
Frieler RA,Meng H,Hafstrom I,et al.Myeloid-specific deletion of the mineralocorticoid receptorreduces infarct volume and alters inflammation during cerebral ischemia[J].Stroke,2011,42(4):179-185.
|
[16] |
Lim HY,Muller N,Ferlisi EM,et al.Glucocorticoids exert opposing effects on macrophage function dependent on their concentration[J].Immunology,2007,122(13):47-53.
|
[17] |
McColl A,Michlewska S,Mirone L,et al.Effects of glucocorticoidson apoptosis and clearance of apoptotic cells[J].Sci World J,2007,7(6):1165-1181.
|
[18] |
Agnes E, Coutinho, Karen E, et al. The anti-inflammatory and immunosuppressive effects of glucocorticoids,recent developments and mechanistic insights[J].Mol Cell Endocrinol,2011,335(1):2-13.
|
[19] |
Bassem HD,Selma FW,Donald BD.TNF-α and glucocorticoid receptor interaction in L6 muscle cells:a cooperative downregulation of myosin heavy chain[J].Steroids,2007,72(9/10):705-712.
|
[20] |
Etuk IA,Kaphalia L,Ferlisi EM,et al.The effect of TNF-alpha on glucocorticoid receptor translocation[J].J Allergy Clin Immun,2012,2(129):194-200.
|
[21] |
Lin LH,Nian LY.Glucocorticoid-induced leucine zipper(GILZ)antagonizes tumor necrosis factor-alpha(TNF-α)inhibition of mesenchymal stem cell osteogenic differentiation[J].Bone,2010,47(5):417-423.
|
[22] |
Elena AB,Jose MB,Esteban RR,et al.Glucocorticoids in rheumatoid arthritis:almost always or hardly ever[J].Reumatol Clin,2011,7(6):407-411.
|
[23] |
Smolen JS,Landewe R,Carlstrom K,et al.EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs[J].Ann Rheum Dis,2010,69(6):964-975.
|
[24] |
Braun J,Baraliakos X.2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis[J].Ann Rheum Dis,2011,70(6):896-904.
|
[25] |
Zhang W,Doherty M,Ibrahim HM,et al.EULAR recommendations for calcium pyrophosphate deposition.Part II:management[J].Ann Rheum Dis,2011,70(4):571-575.
|
[26] |
Kirwan JR.The effect of glucocorticoids on joint destruction in rheumatoid arthritis[J].N Engl J Med,1995,333(3):142-146.
|
[27] |
Graudal N,Jürgens G.Similar effects of disease-modifying anti-rheumatic drugs,glucocorticoids,and biological agents on radiographic progression in rheumatoid arthritis[J].Arthritis Rheum,2010,62(1):2852-2856.
|
[28] |
Buttgereit F,Burmester GR,Lipworth BJ.Optimised glucocorticoid therapy:the sharpening of an old spear[J].Lancet,2005,365(26):801-803.
|
[29] |
Cato AC,Schacke H,Sterry W,Asadullah K.The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy[J].Curr Drug Targets Inflamm Allergy,2004,3(12):347-353.
|
[30] |
Schacke H,Docke WD,Asadullah K.Mechanisms involved in the side effects of glucocorticoids[J].Pharmacol Ther,2002,96(11):23-43.
|
[31] |
Cong ZD, Yao Y, Xue BF, et al. Clinical analysis of Chinese patients with rheumatoid arthritis treated with leflunomide and methotrexate combined with different dosages of glucocorticoid[J].Curr Ther Res,2012,73(4/5):123-133.
|
[32] |
Straub RH,Dhabhar FS,Bijlsma JW,et al.How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis[J].Arthritis Rheum,2005,52(1):16-26.
|
[33] |
Buttgereit F, Burmester GR, Straub RH, et al. Exogenous and endogenous glucocorticoids in rheumatic diseases[J].Arthritis Rheum,2011,63(1):1-9.
|
[34] |
Morgan SA,Tomlinson JW.11beta-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes[J].Expert Opin Inv Drug,2010,19(9):1067-1076.
|
[35] |
Wang M.Inhibitors of 11beta-Hydroxysteroid dehydrogenase type 1 in antidiabetic therapy[J].Handb Exp Pharmacol,2011,17(5):127-146.
|
[36] |
Haas CS,Creighton CJ,Pi X,et al.Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins[J].Arthritis Rheum,2006,54(7):2047-2060.
|
[37] |
Cornelia MS,Cindy S,Perry LA,et al.Glucocorticoid[J].Best Pract Res Clin Rheumatol,2011,25(6):891-900.
|
[38] |
Hoes JN,Jacobs JW,Verstappen SM,et al.Adverse events of low-to medium-dose oral glucocorticoids in inflammatory diseases:a meta-analysis[J].Ann Rheum Dis,2009,68(12):1833-1838.
|
[39] |
Ravindran V,Rachapalli S,Choy EH.Safety of medium to long term glucocorticoid therapy in rheumatoid arthritis:a meta-analysis[J].Rheumatology,2009,48(1):807-811.
|
[40] |
Caporali R,Cimmino MA,Montecucco C,et al.Glucocorticoid treatment of polymyalgia rheumatica[J].Clin Exp Rheumatol,2011,29(5):S143-S147.
|
[41] |
Silva JAP,Jacobs JWG,Kirwan JR,et al.Safety of low dose glucocorticoid treatment in rheumatoid arthritis:published evidence and prospective trial data[J].Ann Rheum Dis,2006,65(5):285-293.
|
[42] |
Emmanuelle D,Adeline RW,Gossec L,et al.Use of glucocorticoids in rheumatoid arthritis-Pratical modalities of glucocorticoid therapy:recommendations for clinical practice based on data from the literature and expert opinion[J].Joint Bone Spine,2010,77(5):451-457.
|
[43] |
Gorter SL,Bijlsma JW,Cutolo M,et al.Current evidence for the management of rheumatoid arthritis with glucocorticoids:a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis[J].Ann Rheum Dis,2010,69(5):1010-1014.
|
[44] |
Sara KT,Bonnie B,Karen HC.Sexual disparities in the incidence and course of SLE and RA[J].Clin Immunol,2013,149(2):211-218.
|
[45] |
Mohamad MN, Abeer ME. Sexual performance in rheumatoid arthritis patients—An unnoticed problem[J].The Egyptian Rheumatologist,2013,35(4):201-205.
|
[46] |
Posma E,Moes H,Heineman MJ,et al.The effect of testosterone on cytokine production in the specific and non-specific immuneresponse[J].Am J Reprod Immunol,2004,52(2):237-243.
|
[47] |
Delia AG,Buenaventura BD.Sex hormones and autoimmunity[J].Immunol Lett,2010,133(5):6-13.
|
[48] |
Calippe B, Douin EV, Laffargue M, et al. Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation:involvement of the phosphatidylinositol 3-kinase pathway[J].J Immunol,2008,180(4):7980-7988.
|
[49] |
Lelu K,Laffont S.Estrogen receptor alpha signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis[J].J Immunol,2011,187(3):2386-2393.
|
[50] |
Mehtap P,Akif HK.Effects of 17β-estradiol and progesterone on the production of adipokines in differentiating 3T3-L1 adipocytes:role of Rho-kinase[J].Cytokine,2015,72(1):130-134.
|
[51] |
Takashi N,Yuuki I,Takahiro M,et al.Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts[J].Cell,2007,130(5):811-823.
|
[52] |
Kazuki I, Erina I, Yuuki I. Female sex hormones ameliorate arthritis in SKG mice[J].Biochem Biophys Res Commun,2013,434(4):740-745.
|
[53] |
Nathalie CB,Axelle P,Philippe B.The immninent dawn of SPRMs in obstetrics and gynecology[J].Mol Cell Endocrinol,2012,358(2):232-243.
|
[54] |
Abarca RE,Pacheco YJ,Campos RR,et al.Glucocorticoids and estrogens modulate the NF-κB pathway differently in the micro-and macrovasculature[J].Med Hypotheses,2013,81(6):1078-1082.
|