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1,2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展

胡玥, 陈周, 罗晓星, 薛小燕

胡玥, 陈周, 罗晓星, 薛小燕. 1,2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展[J]. 中国药科大学学报, 2016, 47(1): 112-117. DOI: 10.11665/j.issn.1000-5048.20160117
引用本文: 胡玥, 陈周, 罗晓星, 薛小燕. 1,2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展[J]. 中国药科大学学报, 2016, 47(1): 112-117. DOI: 10.11665/j.issn.1000-5048.20160117
HU Yue, CHEN Zhou, LUO Xiaoxing, XUE Xiaoyan. Research progress of 1, 2-dilinoleyloxy-3-dimethylaminopropane-based cationic lipid nanoparticle[J]. Journal of China Pharmaceutical University, 2016, 47(1): 112-117. DOI: 10.11665/j.issn.1000-5048.20160117
Citation: HU Yue, CHEN Zhou, LUO Xiaoxing, XUE Xiaoyan. Research progress of 1, 2-dilinoleyloxy-3-dimethylaminopropane-based cationic lipid nanoparticle[J]. Journal of China Pharmaceutical University, 2016, 47(1): 112-117. DOI: 10.11665/j.issn.1000-5048.20160117

1,2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展

基金项目: 国家自然科学基金资助项目(No.81402975);陕西省自然科学基础研究计划资助项目(No.2014JM4105)

Research progress of 1, 2-dilinoleyloxy-3-dimethylaminopropane-based cationic lipid nanoparticle

  • 摘要: 阳离子脂质纳米粒具有安全、高效和粒径可控的优点,现已成为核酸药物体内外递送载体的研究热点。该纳米粒的重要组分为阳离子脂质,其中以1,2-二亚油酸-3-二甲基氨丙烷(DLinDMA)及其衍生物为代表的新型材料,因递药效能高,生物相容性好而受到广泛关注。本文介绍了此类阳离子脂质的结构及特点,并对DlinDMA纳米粒的构造、药物递送机制和临床应用进行了综述。
    Abstract: Cationic lipid nanoparticles possessing favorable biocompatibility and controllable particle size have attracted increasing attention in the field of non-viral vectors for delivering nucleic acids in vitro and in vivo. 1, 2-Dilinoleyloxy-3-dimethylaminopropane(DLinDMA)and its derivatives, one kind of most important cationic lipid materials, have been widely studied as the main composition of cationic lipid nanoparticles. This paper summarizes the structure, characteristics and clinical application of DLinDMA nanoparticles.
  • [1] Bai H.Design,synthesis and antibacterial activity of antisense peptide nucleic acid targeting bacterial RNA polymerase primary σ70[D].Xi′an:the Fourth Military Medical University,2011.
    [2] Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates[J].Nature,2006,441(7089):111-114.
    [3] Semple SC,Akinc A,Chen J,et al.Rational design of cationic lipids for siRNA delivery[J].Nat Biotechnol,2010,28(2):172-176.
    [4] Miller AD.Delivery of RNAi therapeutics:work in progress[J].Expert Rev Med Devices,2013,10(6):781-811.
    [5] Zhou YD,Li J.Cationic liposome used as gene vector:materials and preparation techniques[J].Prog Pharm Sci(药学进展),2009,33(7):297-304.
    [6] Kanasty R, Dorkin JR, Vegas A, et al. Delivery materials for siRNA therapeutics[J].Nat Mater,2013,12(11):967-977.
    [7] Miller AD.Delivering the promise of small ncRNA therapeutics[J].Ther Deliv,2014, 5(5):569-589.
    [8] Kolli S,Wong SP,Harbottle R,et al.pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo[J].Bioconjug Chem,2013, 24(3):314-332.
    [9] Kenny GD,Kamaly N,Kalber TL,et al.Novel multifunctional nanoparticle mediates siRNA tumour delivery,visualisation and therapeutic tumour reduction in vivo[J].J Control Release,2011, 149(2):111-116.
    [10] Medina-Kauwe LK,Xie J,Hamm-Alvarez S.Intracellular trafficking of nonviral vectors[J].Gene Ther,2005, 12(24):1734-1751.
    [11] Kang MR,Yang G,Place RF,et al.Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth[J].Cancer Res,2012, 72(19):5069-5079.
    [12] Guo J,Cahill MR,McKenna SL,et al.Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia[J].Biotechnol Adv,2014, 32(8):1396-1409.
    [13] Kajimoto K,Sato Y,Nakamura T,et al.Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo[J].J Control Release,2014,190:593-606.
    [14] Haynes M,Huang L.Hepatic RNA interference:delivery by synthetic vectors[J].Drug Deliv Transl Res,2014,4(1):61-73.
    [15] Hobo W,Novobrantseva TI,Fredrix H,et al.Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation[J].Cancer Immunol Immunother,2013, 62(2):285-297.
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出版历程
  • 刊出日期:  2016-02-24

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