• 中国中文核心期刊
  • 中国科学引文数据库核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
高级检索

青蒿素类药物制剂中国专利申请技术分析

蒋薇薇, 张磊, 沈雁

蒋薇薇, 张磊, 沈雁. 青蒿素类药物制剂中国专利申请技术分析[J]. 中国药科大学学报, 2016, 47(2): 242-246. DOI: 10.11665/j.issn.1000-5048.20160219
引用本文: 蒋薇薇, 张磊, 沈雁. 青蒿素类药物制剂中国专利申请技术分析[J]. 中国药科大学学报, 2016, 47(2): 242-246. DOI: 10.11665/j.issn.1000-5048.20160219
shu
JIANG Weiwei, ZHANG Lei, SHEN Yan. Analysis of China patent application for the pharmaceutical preparations of artemisinins[J]. Journal of China Pharmaceutical University, 2016, 47(2): 242-246. DOI: 10.11665/j.issn.1000-5048.20160219
Citation: JIANG Weiwei, ZHANG Lei, SHEN Yan. Analysis of China patent application for the pharmaceutical preparations of artemisinins[J]. Journal of China Pharmaceutical University, 2016, 47(2): 242-246. DOI: 10.11665/j.issn.1000-5048.20160219
shu

青蒿素类药物制剂中国专利申请技术分析

  • 1.

    国家知识产权局专利局专利审查协作江苏中心

  • 2.

    中国药科大学药学院药剂学教研室

基金项目: 国家自然科学基金资助项目(No.81501579)；江苏省自然科学基金资助项目(No.BK20150702)；江苏高校优势学科建设工程资助项目

Analysis of China patent application for the pharmaceutical preparations of artemisinins

摘要

    摘要
  • 摘要: 青蒿素类化合物除抗疟作用外，在治疗艾滋病和肿瘤等疾病方面具有潜在的临床应用价值。目前临床上应用的青蒿素类药物制剂普遍存在溶解度差、首过效应高、生物利用度低、给药频繁、疟原虫复燃率高等缺点，因此，采用制药新技术，研发青蒿素类药物新制剂以克服传统制剂的不足成为研究热点之一。笔者通过文献检索，对青蒿素类药物制剂的中国专利申请状况和相关专利技术进行了分析，旨在为国内研发机构和相关企业对于青蒿素类药物制剂的后期开发、专利保护策略以及知识产权布局提供有益的参考和建议。
    Abstract: Artemisinins were reported to have the potential efficacy of anticancer, anti-AIDS, etc. , besides antimalaria. Clinical application of current dosage forms has significant drawbacks, i. e. , poor solubility, high first pass effect, low bioavailability, frequent dosing, low bioavailability, high plasmodium recrudescence rate, etc. To overcome these drawbacks, a hot area of research is to develop novel artemisinin dosage forms by applying new preparation technology. Here we summarized the related patents application technology in order to provide helpful references and recommendations on the development of artemisinin dosage forms, patents protection and layout of intellectual properties to the domestic R&D institutes and pharmaceutical manufacturers.
    • HTML全文
    • 参考文献(14)
  • [1] Efferth T,Oesch F.Oxidative stress response of tumor cells:microar-ray-based comparison between artemisinins and anthracyclines[J].Biochem Pharmacol,2004,68(1):3-10.
    [2] Zhu YH.Advances in artemisinin[J].Sci Technol Rev(科技导报),2015,33(20):36-41.
    [3] Chen YY.Advances in the antitumor activity of dihydro-artemisinin[J].J Guangxi Univ Tradit Chin Med(广西中医药大学学报),2012,15(3):72-74.
    [4] Davis B,Ladner J,Sams K,et al.Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries[J].Malar J,2013,12(5):646-654.
    [5] Lu T,Zhang JW,Ai FW.Advances in the drug delivery systems and formulation techniques of Artemisinins with high bioavailability[J].Chin Tradit Pat Med(中成药),2015,37(1):180-183.
    [6] Zhang YH,Wang LJ,Gan LL,et al.Advances in the preparation and clinical application of artemether[J].Chongqing Med(重庆医学),2014,29:3967-3970.
    [7] Shen S,Liu SZ,Du MB.Overview of the antimalarial agents of artemisinins[J].Chin J Inf Tradit Chin Med(中国中医药信息杂志),2015,22(10):125-128.
    [8] Vries PJ,Diet TK.Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria[J].Drugs,1996,52(6):818-836.
    [9] Shahzad Y,Sohail S,Arshad MS,et al.Development of solid dispersions of artemisinin for transdermal delivery[J].Int J Pharm,2013,457(1):197-205.
    [10] Jain K,Sood S,Gowthamarajan K.Optimization of artemether-loaded NLC for intranasal delivery using central composite design[J].Drug Deliv,2015,22(7):940-954.
    [11] Kakran M,Sahoo NG,Li L,et al.Dissolution enhancement of artemisinin with β-cyclodextrin[J].Chem Pharm Bull,2011,59(5):646-652.
    [12] Wang B,Liu GM.The role of patents in international competition:from the lessons and experiences of artemisinin[J].China Invention Patent(中国发明与专利),2011(7):42-45.
    [13] Ye ZG.What brought from patent:review and reflection in the development of artemisinins antimalarial agents[J].China Invention Patent(中国发明与专利),2011(7):21-23.
    [14] Cui FD.Pharmaceutics(药剂学)[M].2nd ed.Beijing:Chinese Medical Science and Technology Publishing House.2011:15.
    • 相关文章
    • 施引文献
    • 资源附件(0)
计量
  • 文章访问数:  1240
  • HTML全文浏览量:  1
  • PDF下载量:  2859
  • 被引次数: 0
出版历程
  • 刊出日期:  2016-04-24

目录

摘要
HTML全文
    参考文献(14)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    版权所有：《中国药科大学学报》编辑部苏ICP备05007142号

    地址：江苏省南京市鼓楼区童家巷24号（210009）电话: 025-83271566E-mail: xuebao@cpu.edu.cn

    本系统由 北京仁和汇智信息技术有限公司 开发  百度统计

    访问量：452076

    x 关闭 永久关闭