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鱼腥草的抗炎活性成分

许贵军, 李志军, 王琦, 谭杰军, 施国善, 齐威, 李迪, 王有鹏

许贵军, 李志军, 王琦, 谭杰军, 施国善, 齐威, 李迪, 王有鹏. 鱼腥草的抗炎活性成分[J]. 中国药科大学学报, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308
引用本文: 许贵军, 李志军, 王琦, 谭杰军, 施国善, 齐威, 李迪, 王有鹏. 鱼腥草的抗炎活性成分[J]. 中国药科大学学报, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308
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XU Guijun, LI Zhijun, WANG Qi, TAN Jiejun, SHI Guoshan, QI Wei, LI Di, WANG Youpeng. Isolation and identification of anti-inflammatory constituents from Houttuynia cordata[J]. Journal of China Pharmaceutical University, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308
Citation: XU Guijun, LI Zhijun, WANG Qi, TAN Jiejun, SHI Guoshan, QI Wei, LI Di, WANG Youpeng. Isolation and identification of anti-inflammatory constituents from Houttuynia cordata[J]. Journal of China Pharmaceutical University, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308
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鱼腥草的抗炎活性成分

  • 1.

    黑龙江中医药大学附属第二医院

  • 2.

    江苏神龙药业有限公司

  • 3.

    黑龙江中医药大学

基金项目: 国家自然科学基金资助项目(No.81473724)；黑龙江省自然科学基金资助项目(No.D201274)；哈尔滨市应用技术研究与开发项目(No.2014RFXJ098)；黑龙江中医药大学科研基金资助项目(No.X201103)

Isolation and identification of anti-inflammatory constituents from Houttuynia cordata

摘要

    摘要
  • 摘要: 采用硅胶、反相高效液相色潽等各种柱色谱技术，并结合现代波谱学方法及理化性质，从鱼腥草(Houttuynia cordata)醇提物乙酸乙酯部位中共分离鉴定了10个化合物，其中1个酚苷类新化合物sequinoside L( 1 )以及9个已知化合物，分别为:sequinoside K( 2 )，绿原酸甲酯( 3 )，绿原酸( 4 )，对苯二酚( 5 )，香草酸( 6 )，金丝桃苷( 7 )，异槲皮苷( 8 )，槲皮素( 9 )，槲皮苷( 10 )。另外，利用脂多糖诱导的巨噬细胞RAW264.7对分离得到的化合物 1 ~ 10 进行体外抗炎活性评价。结果表明，化合物 1 、 2 、 6 和 9 具有显著的抗炎活性，与阳性对照药地塞米松活性相似。
    Abstract: Ten compounds were isolated and purified from the ethyl acetate fraction of Houttuynia cordata by silica gel and ODS column chromatographies. The chemical structures of the compounds were identified on the basis of physicochemical properties as well as spectral data. These isolated compounds were elucidated as sequinoside L( 1 ), a new phenolic glycoside, together with nine known compounds, including sequinoside K( 2 ), methyl chlorogenate( 3 ), chlorogenic acid( 4 ), hydroquinone( 5 ), vanillic acid( 6 ), hyperin( 7 ), isoquercitrin( 8 ), quercetin( 9 ), and quercitrin( 10 ). In addition, the anti-inflammatory activities of compounds 1 - 10 were evaluated in LPS-induced RAW264. 7 macrophages. Among them, compounds 1 , 2 , 6 and 9 showed potent anti-inflammatory activity which was similar to that of positive control dexamethasone.
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    • 参考文献(14)
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  • 刊出日期:  2016-06-24

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