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杨梅素-咖啡因共晶的制备及其单晶结构解析

Preparation of myricetin-caffeine cocrystal and its single crystal analysis

  • 摘要: 采用混悬液法制备杨梅素-咖啡因共晶,并通过溶剂缓慢挥发法培养其单晶;X射线衍射图谱表明两种方法获得的共晶晶型一致。单晶结构解析表明共晶晶体为单斜晶系,空间群为P21/n,结构中的氢键连接位置为杨梅素B环的4′-OH和A环的7-OH分别与咖啡因8位C=N和2位的C=O形成氢键。特性溶出实验表明杨梅素-咖啡因共晶较杨梅素晶体的溶出度提高了17倍。

     

    Abstract: Myricetin(MYR)was cocrystallized with caffeine(CAF)by suspension and the single crystal of MYR-CAF cocrystal was cultured by slow solvent evaporation. Cocrystals obtained by two different methods were the same in crystal form after characterization with X-ray diffraction. Structural analysis of single crystal of MYR-CAF showed that its crystal system and the space group were monoclinic and P21/n, respectively. In MYR-CAF cocrystal, 4′-OH in ring B and 7-OH in ring A of MYR interacted with CAF at(8)C=N and(2)C=O through hydrogen bonds. In comparison to the original MYR crystal, the intrinsic dissolution rate of MYR was significantly enhanced for about 17-fold after cocrystallization with CAF.

     

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