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山茱萸总萜对db/db糖尿病小鼠的降血糖作用

徐志猛, 朱晶晶, 江振洲, 楼凤昌, 王涛

徐志猛, 朱晶晶, 江振洲, 楼凤昌, 王涛. 山茱萸总萜对db/db糖尿病小鼠的降血糖作用[J]. 中国药科大学学报, 2016, 47(3): 337-341. DOI: 10.11665/j.issn.1000-5048.20160315
引用本文: 徐志猛, 朱晶晶, 江振洲, 楼凤昌, 王涛. 山茱萸总萜对db/db糖尿病小鼠的降血糖作用[J]. 中国药科大学学报, 2016, 47(3): 337-341. DOI: 10.11665/j.issn.1000-5048.20160315
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XU Zhimeng, ZHU Jingjing, JIANG Zhenzhou, LOU Fengchang, WANG Tao. Hypoglycemic effects of terpenes from Fructus Corni on db/db diabetic mice[J]. Journal of China Pharmaceutical University, 2016, 47(3): 337-341. DOI: 10.11665/j.issn.1000-5048.20160315
Citation: XU Zhimeng, ZHU Jingjing, JIANG Zhenzhou, LOU Fengchang, WANG Tao. Hypoglycemic effects of terpenes from Fructus Corni on db/db diabetic mice[J]. Journal of China Pharmaceutical University, 2016, 47(3): 337-341. DOI: 10.11665/j.issn.1000-5048.20160315
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山茱萸总萜对db/db糖尿病小鼠的降血糖作用

  • 1.

    中国药科大学江苏省新药筛选重点实验室

  • 2.

    江苏吴中苏药医药开发有限责任公司

  • 3.

    中国药科大学江苏省药效研究与评价服务中心

Hypoglycemic effects of terpenes from Fructus Corni on db/db diabetic mice

摘要

    摘要
  • 摘要: 为评价山茱萸总萜对2型糖尿病的降血糖作用，对db/db糖尿病小鼠每日灌胃给予25，50，100 mg/kg山茱萸总萜共10周，每2周眼眶采血测定空腹血糖1次。于末次给药24 h后采血测定空腹血糖、胰岛素(Ins)、糖化血清蛋白(GSP)、总胆固醇(TC)、三酰甘油(TG)。给药第8和10周分别进行葡萄糖和淀粉糖耐量试验。结果显示，给药4周后，山茱萸总萜各剂量组db/db小鼠的空腹血糖有明显降低(P<；0.05)。给药10周后，山茱萸总萜25，50，100 mg/kg组db/db小鼠血清中TC、TG水平显著降低(P<；0.05)，血清糖化蛋白水平明显降低(P<；0.05)，db/db小鼠的葡萄糖耐量和灌胃淀粉糖耐量也有明显改善(P<；0.05)。研究结果提示，山茱萸总萜可调节体内糖、脂等代谢过程，对糖尿病具有一定的治疗作用。
    Abstract: To investigate the hypoglycemic effects of terpenes from Fructus Corni(TFC)on type 2 diabetes mellitus, the db/db diabetic mice were intragastrically administered with 25, 50, 100 mg/kg of TFC for 10 weeks. The fasting blood glucose, insulin(Ins), glycosylated serum protein(GSP), total cholesterol(TC)and triglyceride(TG)levels were determined. At weeks 8 and 10, intraperitoneal injections of glucose and gavage starch tolerance tests were performed, respectively. The db/db mice showed obvious obesity. Each dose of TFC could significantly reduce the body weight of db/db mice(P< 0. 05). After 4 weeks of administration, all doses of TFC significantly reduced the fasting blood glucose of db/db mice(P< 0. 05). The serum TC, TG levels were also significantly decreased in the TFC middle- and high-dose groups(P< 0. 05). In addition, middle- and high-dose of TFC could significantly reduce the level of GSP. Middle- and high-dose of TFC also significantly improve the glucose tolerance and gavage starch tolerance in db/db mice(P< 0. 05). These results suggest that TFC could improve diabetes-related symptoms via regulating glucose and lipids metabolism.
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    • 参考文献(12)
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  • 刊出日期:  2016-06-24

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