• 中国中文核心期刊
  • 中国科学引文数据库核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
高级检索

天然产物防治急性肺损伤的作用机制研究进展

俞苏岚, 余秀, 寇俊萍

俞苏岚, 余秀, 寇俊萍. 天然产物防治急性肺损伤的作用机制研究进展[J]. 中国药科大学学报, 2016, 47(4): 397-403. DOI: 10.11665/j.issn.1000-5048.20160403
引用本文: 俞苏岚, 余秀, 寇俊萍. 天然产物防治急性肺损伤的作用机制研究进展[J]. 中国药科大学学报, 2016, 47(4): 397-403. DOI: 10.11665/j.issn.1000-5048.20160403
shu
YU Sulan, YU Xiu, KOU Junping. Advances in the mechanism research of natural products against acute lung injury[J]. Journal of China Pharmaceutical University, 2016, 47(4): 397-403. DOI: 10.11665/j.issn.1000-5048.20160403
Citation: YU Sulan, YU Xiu, KOU Junping. Advances in the mechanism research of natural products against acute lung injury[J]. Journal of China Pharmaceutical University, 2016, 47(4): 397-403. DOI: 10.11665/j.issn.1000-5048.20160403
shu

天然产物防治急性肺损伤的作用机制研究进展

  • 江苏省中药评价与转化重点实验室，中国药科大学中药复方研究室

基金项目: 国家自然科学基金资助项目(No.81274131)

Advances in the mechanism research of natural products against acute lung injury

摘要

    摘要
  • 摘要: 急性肺损伤(acute lung injury，ALI)是临床上常见的危重病症，发病率和致死率逐年增高，其本质为炎症反应失衡，引发弥漫性肺泡及肺血管内皮细胞损伤、肺组织水肿及肺不张等病理特征。其调控途径涉及NF-κB、MAPK等信号通路和TLRs、PPARγ、腺苷A2A等主要相关受体。天然产物在防治ALI方面日益受到关注，其作用机制研究也不断深入。本文综述近3年来天然产物对ALI病理特征的改善作用及其所涉及的信号通路和相关受体，以期为研制防治ALI的创新药物提供一定线索和依据。
    Abstract: Acute lung injury(ALI)is a common critical disease with increasing morbidity and mortality rate in clinic. Its major pathological cause is the inflammation imbalance, which can cause diffuse alveolar and pulmonary vascular endothelial cell injury, lung edema and atelectasis. Many pathways and receptors, such as NF-κB and MAPK signaling pathways, and the adenosine A2A receptors, Toll-like receptors(TLRs), peroxisome proliferator-activated receptor gamma(PPARγ), etc. are involved in ALI. Nowadays, prevention and treatment of ALI with natural products attract more and more attention. This article reviews the advances in the mechanisms research of natural products in recent three years against ALI so as to provide some references and clues for the development of innovative drugs to prevent and treat ALI.
    • HTML全文
    • 参考文献(52)
  • [1] Ma LJ,Li WP,Jin GF.Research progress of pathogenesis of acute lung injury and acute respiratory distress syndrome[J].Chin J Lung Dis,2013,6(1):65-68.
    [2] Aggarwal S,Gross CM,Kumar S,et al.Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury[J].Am J Respir Cell Mol Biol,2014,50(3):614-625.
    [3] Standiford TJ,Ward PA.Therapeutic targeting of acute lung injury and acute respiratory distress syndrome[J].Transl Res,2016,167(1):183-191.
    [4] Sweeney RM,Griffiths M,McAuley D.Treatment of acute lung injury:current and emerging pharmacological therapies[J].Semin Respir Crit Care Med,2013,34(4):487-498.
    [5] Standiford TJ,Ward PA.Therapeutic targeting of acute lung injury and acute respiratory distress syndrome[J].Transl Res,2016,167(1):183-191.
    [6] Yu S,Shi M,Liu C,et al.Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats[J].Iran J Basic Med Sci,2015,18(1):98-103.
    [7] Huang X,Liu Y,Lu Y,et al.Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status[J].Int Immunopharmacol,2015,26(1):265-271.
    [8] Shu YS,Tao W,Miao QB,et al.Galangin dampens mice lipopolysaccharide-induced acute lung injury[J].Inflammation,2014,37(5):1661-1668.
    [9] Li T,Zhang J,Feng J,et al.Resveratrol reduces acute lung injury in a LPS-induced sepsis mouse model via activation of Sirt1[J].Mol Med Rep,2013,7(6):1889-1995.
    [10] Liu XX,Yu DD,Chen MJ,et al.Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release[J].Int Immunopharmacol,2015,25(2):370-376.
    [11] Wang QS,Li GH,Xu GQ.Acanthoic acid ameliorates lipopolysaccharide-induced acute lung injury[J].Eur J Pharmacol,2015,750:32-38.
    [12] Wu Q,Li H,Qiu J,et al.Betulin protects mice from bacterial pneumonia and acute lung injury[J].Microb Pathog,2014,75:21-28.
    [13] Chen Y,Nie YC,Luo YL,et al.Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice[J].Food Chem Toxicol,2013,58:133-140.
    [14] Kása A,Csortos C,Verin AD.Cytoskeletal mechanisms regulating vascular endothelial barrier function in response to acute lung injury[J].Tissue Barriers,2015,3(1/2):e974448.
    [15] Bao S,Zou Y,Wang B,et al.Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages[J].Int Immunopharmacol,2015,28(1):429-434.
    [16] Tao W,Su Q,Wang H,et al.Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro[J].Int Immunopharmacol,2015,27(1):138-147.
    [17] Zhang Y,Sun K,Liu YY,et al.Ginsenoside Rb1 ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules by intervening in both trans- and paracellular pathway[J].Am J Physiol Gastrointest Liver Physiol,2014,306(4):G289-300.
    [18] Aksu B,Ayvaz S,Aksu F,et al.Effects of sphingosylphosphorylcholine against oxidative stress and acute lung injury induced by pulmonary contusion in rats[J].J Pediatr Surg,2015,50(4):591-597.
    [19] Ma CH,Liu JP,Qu R,et al.Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice[J].Chin J Nat Med,2014,12(11):841-846.
    [20] Fei XJ,Zhu LL,Xia LM,et al.Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-kappaB pathway[J].Genet Mol Res,2014,13(4):10537-10544.
    [21] Tsai CL,Lin YC,Wang HM,et al.Baicalein,an active component of Scutellaria baicalensis,protects against lipopolysaccharide-induced acute lung injury in rats[J].J Ethnopharmacol,2014,153(1):197-206.
    [22] Gao H,Zhu T,Wang DX,et al.Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB[J].PLoS One,2013,8(2):e56407.
    [23] Wang J,Liu YT,Xiao L,et al.Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway[J].Inflammation,2014,37(6):2085-2090.
    [24] Xiao M,Zhu T,Zhang W,et al.Emodin ameliorates LPS-induced acute lung injury,involving the inactivation of NF-κB in mice[J].Int J Mol Sci,2014,15(11):19355-19368.
    [25] Xu M,Cao FL,Zhang YF,et al.Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice[J].Acta Pharmacol Sin,2014,36(2):179-187.
    [26] Qiu J,Yu L,Zhang X,et al.Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-kappaB signaling pathway[J].Int Immunopharmacol,2015,26(1):181-187.
    [27] Xu R,Shang C,Zhao JG,et al.Protective effect of veratric acid on lipopolysaccharide-induced acute lung injury in mice[J].Eur J Pharmacol,2014,740:227-232.
    [28] Huang GJ,Deng JS,Chen CC,et al.Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-kappa B and MAPK pathways in mice[J].J Agric Food Chem,2014,62(23):5321-5329.
    [29] Zhang X,Li C,Li J,et al.Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-kappaB signal pathways[J].Int Immunopharmacol,2015,26(1):229-236.
    [30] Lv H,Zhu C,Liao Y,et al.Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways[J].Respir Physiol Neurobiol,2015,216:43-51.
    [31] Liang XM,Guo GF,Huang XH,et al.Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B[J].J Surg Res,2014,187(2):596-604.
    [32] Yang H,Li Y,Huo P,et al.Protective effect of Jolkinolide B on LPS-induced mouse acute lung injury[J].Int Immunopharmacol,2015,26(1):119-124.
    [33] San Z,Fu Y,Li W,et al.Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice[J].Int Immunopharmacol,2014,19(2):342-350.
    [34] Zhong WT,Jiang LX,Wei JY,et al.Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice[J].J Surg Res,2013,185(1):364-372.
    [35] Gao M,Chen L,Yu H,et al.Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice[J].Int Immunopharmacol,2013,15(2):240-245.
    [36] Li KC,Ho YL,Hsieh WT,et al.Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation[J].Int J Mol Sci,2015,16(1):1736-1754.
    [37] Han HJ,Li M,Son JK,et al.Sauchinone,a lignan from Saururus chinensis,attenuates neutrophil pro-inflammatory activity and acute lung injury[J].Int Immunopharmacol,2013,17(2):471-477.
    [38] Chen WY,Huang YC,Yang ML,et al.Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation[J].Int Immunopharmacol,2014,22(2):409-413.
    [39] Shi X,Sun H,Zhou D,et al.Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats[J].Inflammation,2014,38(2):623-631.
    [40] Li J,Zhao L,He X,et al.Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A2A receptor signaling[J].PLoS One,2013,8(3):e59257.
    [41] Wang C,Huang Q,Wang C,et al.Hydroxysafflor yellow A suppress oleic acid-induced acute lung injury via protein kinase A[J].Toxicol Appl Pharmacol,2013,272(3):895-904.
    [42] Xu F,Lin SH,Yang YZ,et al.The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway[J].Int Immunopharmacol,2013,16(1):1-6.
    [43] Xu C,Chen G,Yang W,et al.Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor(TLR)4-dependent signaling pathways[J].Int Immunopharmacol,2015,28(2):1050-1058.
    [44] Feng G, Sun B, Li TZ. Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-kappaB pathway[J].Int Immunopharmacol,2015,26(2):392-400.
    [45] Liu YL,Liu YJ,Liu Y,et al.Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways[J].Int Immunopharmacol,2014,23(2):649-657.
    [46] Zhang Z,Chen N,Liu JB,et al.Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway[J].Mol Med Rep,2014,10(1):101-106.
    [47] Tang Y,Chen Y,Chu Z,et al.Protective effect of cryptotanshinone on lipopolysaccharide-induced acute lung injury in mice[J].Eur J Pharmacol,2014,723:494-500.
    [48] Wang X,Zhang L,Duan W,et al.Anti-inflammatory effects of triptolide by inhibiting the NF-kappaB signalling pathway in LPS-induced acute lung injury in a murine model[J].Mol Med Rep,2014,10(1):447-452.
    [49] Wang G,Liu L,Zhang Y,et al.Activation of PPARγ attenuates LPS-induced acute lung injury by inhibition of HMGB1-RAGE levels[J].Eur J Pharmacol,2014,726:27-32.
    [50] Wei D,Huang Z.Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice[J].Inflammation,2014,37(4):1307-1316.
    [51] Shen Y,Sun Z,Guo X.Citral inhibits lipopolysaccharide-induced acute lung injury by activating PPAR-γ[J].Eur J Pharmacol,2015,747:45-51.
    [52] He X,Hu JL,Li J,et al.A feedback loop in PPARgamma-adenosine A2A receptor signaling inhibits inflammation and attenuates lung damages in a mouse model of LPS-induced acute lung injury[J].Cell Signal,2013,25(9):1913-1923.
    • 相关文章
    • 施引文献(9)

  • 期刊类型引用(4)

    1. 宋永真，李雅静，张振凌，王胜超. 曼地亚红豆杉酒炙工艺及质量标准研究. 中医学报. 2024(05): 1068-1075 . 百度学术
    2. 剡槿熙，臧明伍，刘贺，徐晨晨，史宇璇，白京，赵燕，郝静怡，张亚茹. 二萜类化合物在肉类食品保鲜防腐中的应用研究进展. 食品科学. 2024(13): 282-291 . 百度学术
    3. 王楠楠，蔡婷婷，童晔玲，刘霞，朱婉萍，江石平，赵桂芝. 基于NF-κB信号通路的HTRF法筛选红豆杉中抗气道炎症有效活性成分研究. 浙江中医杂志. 2023(08): 553-556 . 百度学术
    4. 傅贵江. 杉木人工林抚育间伐对套种南方红豆杉的影响. 武夷科学. 2022(01): 39-43 . 百度学术

    其他类型引用(5)

    • 资源附件(0)
计量
  • 文章访问数:  857
  • HTML全文浏览量:  0
  • PDF下载量:  2634
  • 被引次数: 9
出版历程
  • 刊出日期:  2016-08-24

目录

摘要
HTML全文
    参考文献(52)
    相关文章
    施引文献(9)
    资源附件(0)

    /

    返回文章
    返回

    版权所有：《中国药科大学学报》编辑部苏ICP备05007142号

    地址：江苏省南京市鼓楼区童家巷24号（210009）电话: 025-83271566E-mail: xuebao@cpu.edu.cn

    本系统由 北京仁和汇智信息技术有限公司 开发  百度统计

    访问量：400387

    x 关闭 永久关闭