Abstract:
The inhibition effects of the extracts of five
Verbenaceae herbs,
Clerodendrum fortunatum L. ,
Clerodendrum japonicum(Thunb
. )Sweet,
Clerodendrum philippinum Schauer var. simplex Moldenke,
Callicarpa longissima(Hemsl. )Merr
. and
Pygmaeopremna herbacea, were investigated by cell hemolysis model
in vitro on classical and alternative complement activation pathways. The water extracts of
Pygmaeopremna herbacea, the water extract and the ethanol extract of
Clerodendrum fortunatum L. , the water extract and the ethanol extract of
Callicarpa longissima(Hemsl. )Merr. , the ethanol extracts of
Clerodendrum japonicum(Thunb. )Sweet and
Clerodendrum philippinum Schauer var. simplex Moldenke showed inhibition cell hemolysis effects on the classical pathway. Their CH
50 values were 0. 092±0. 008, 0. 074±0. 008, 0. 088±0. 006, 0. 134±0. 017, 0. 123±0. 010, 0. 380±0. 080, and 0. 200±0. 015 g/L, respectively. The water extracts of
Pygmaeopremna herbacea and
Callicarpa longissima(Hemsl. )Merr. and the ethanol extract of
Clerodendrum fortunatum L. showed inhibition cell hemolysis effects on alternative pathway. Their AP
50 values were 0. 533±0. 033, 0. 758±0. 031, and 0. 362±0. 029 g/L, respectively. Five
Verbenaceae herbs appear good anticomplementary effects
in vitro. The ethanol extract of
Clerodendrum fortunatum L. showed the best inhibitory activity.
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