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5种马鞭草科药用植物的抗补体活性

焦杨, 邹录惠, 邱莉, 谢云峰, 罗艳, 谢集照

焦杨, 邹录惠, 邱莉, 谢云峰, 罗艳, 谢集照. 5种马鞭草科药用植物的抗补体活性[J]. 中国药科大学学报, 2016, 47(4): 469-473. DOI: 10.11665/j.issn.1000-5048.20160413
引用本文: 焦杨, 邹录惠, 邱莉, 谢云峰, 罗艳, 谢集照. 5种马鞭草科药用植物的抗补体活性[J]. 中国药科大学学报, 2016, 47(4): 469-473. DOI: 10.11665/j.issn.1000-5048.20160413
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JIAO Yang, ZOU Luhui, QIU Li, XIE Yunfeng, LUO Yan, XIE Jizhao. Anticomplementary effects of the extracts of five Verbenaceae herbs in vitro[J]. Journal of China Pharmaceutical University, 2016, 47(4): 469-473. DOI: 10.11665/j.issn.1000-5048.20160413
Citation: JIAO Yang, ZOU Luhui, QIU Li, XIE Yunfeng, LUO Yan, XIE Jizhao. Anticomplementary effects of the extracts of five Verbenaceae herbs in vitro[J]. Journal of China Pharmaceutical University, 2016, 47(4): 469-473. DOI: 10.11665/j.issn.1000-5048.20160413
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5种马鞭草科药用植物的抗补体活性

  • 1.

    广西医科大学药学院

  • 2.

    广西高校生物分子医学研究重点实验室

基金项目: 广西自然科学基金资助项目(No.2013GXNSFBB053001)；广西教育厅高校科研项目资助(No.200911MS26)

Anticomplementary effects of the extracts of five Verbenaceae herbs in vitro

摘要

    摘要
  • 摘要: 采用细胞溶血法考察了千解草(Pygmaeopremna herbacea)、白花灯笼(Clerodendrum fortunatum L.)、尖尾枫［Callicarpa longissima(Hemsl.)Merr.］、赪桐［Clerodendrum japonicum(Thunb.)Sweet］及臭茉莉(Clerodendrum philippinum Schauer var.simplex Moldenke)等5种马鞭草科药用植物提取物经典途径和旁路途径的抗补体活性。结果表明:千解草水提取物、白花灯笼水提取物和醇提取物、尖尾枫水提取物和醇提取物、赪桐醇提取物及臭茉莉醇提取物有较强的经典途径抗补体活性，对经典途径的抗补体活性(CH50)分别为0.092±0.008，0.074±0.008，0.088±0.006，0.134±0.017，0.123±0.010，0.380±0.080及0.200±0.015 g/L；仅千解草和尖尾枫水提取物及白花灯笼醇提取物具有旁路途径抗补体活性，对旁路途径的抗补体活性(AP50)分别为0.533±0.033，0.758±0.031和0.362±0.029 g/L。因此，5种植物均具有不同程度的抗补体活性，其中白花灯笼醇提取物抗补体活性最强。
    Abstract: The inhibition effects of the extracts of five Verbenaceae herbs, Clerodendrum fortunatum L. , Clerodendrum japonicum(Thunb. )Sweet, Clerodendrum philippinum Schauer var. simplex Moldenke, Callicarpa longissima(Hemsl. )Merr. and Pygmaeopremna herbacea, were investigated by cell hemolysis model in vitro on classical and alternative complement activation pathways. The water extracts of Pygmaeopremna herbacea, the water extract and the ethanol extract of Clerodendrum fortunatum L. , the water extract and the ethanol extract of Callicarpa longissima(Hemsl. )Merr. , the ethanol extracts of Clerodendrum japonicum(Thunb. )Sweet and Clerodendrum philippinum Schauer var. simplex Moldenke showed inhibition cell hemolysis effects on the classical pathway. Their CH50 values were 0. 092±0. 008, 0. 074±0. 008, 0. 088±0. 006, 0. 134±0. 017, 0. 123±0. 010, 0. 380±0. 080, and 0. 200±0. 015 g/L, respectively. The water extracts of Pygmaeopremna herbacea and Callicarpa longissima(Hemsl. )Merr. and the ethanol extract of Clerodendrum fortunatum L. showed inhibition cell hemolysis effects on alternative pathway. Their AP50 values were 0. 533±0. 033, 0. 758±0. 031, and 0. 362±0. 029 g/L, respectively. Five Verbenaceae herbs appear good anticomplementary effects in vitro. The ethanol extract of Clerodendrum fortunatum L. showed the best inhibitory activity.
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  • 刊出日期:  2016-08-24

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