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新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用

季一兵, 段飞飞, 郝单单, 陈建秋

季一兵, 段飞飞, 郝单单, 陈建秋. 新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用[J]. 中国药科大学学报, 2017, 48(1): 53-59. DOI: 10.11665/j.issn.1000-5048.20170108
引用本文: 季一兵, 段飞飞, 郝单单, 陈建秋. 新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用[J]. 中国药科大学学报, 2017, 48(1): 53-59. DOI: 10.11665/j.issn.1000-5048.20170108
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JI Yibing, DUAN Feifei, HAO Dandan, CHEN Jianqiu. Preparation and application of novel polysulfone chiral membranes for the separation of tryptophan enantiomers[J]. Journal of China Pharmaceutical University, 2017, 48(1): 53-59. DOI: 10.11665/j.issn.1000-5048.20170108
Citation: JI Yibing, DUAN Feifei, HAO Dandan, CHEN Jianqiu. Preparation and application of novel polysulfone chiral membranes for the separation of tryptophan enantiomers[J]. Journal of China Pharmaceutical University, 2017, 48(1): 53-59. DOI: 10.11665/j.issn.1000-5048.20170108
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新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用

  • 中国药科大学分析化学教研室

Preparation and application of novel polysulfone chiral membranes for the separation of tryptophan enantiomers

摘要

    摘要
  • 摘要: 为了研制新型聚砜手性膜，采用十二酰氯与β-环糊精反应，制备一种新型的十二酰基-β-环糊精，然后将其添加到聚砜铸膜液中，采用浸入沉淀相转化法制备十二酰基-β-环糊精/聚砜手性膜。分别考察十二酰基-β-环糊精的添加量对膜的纯水通量、牛血清白蛋白(BSA)截留率和手性拆分性能的影响。膜的形态采用扫描电子显微镜进行表征。实验结果表明，随着十二酰基-β-环糊精含量的增加，膜的孔径发生变化，膜的支撑层中出现指状孔结构。因此，膜的水通量显著上升而截留率略有降低。当十二酰基-β-环糊精的添加量在2%~3.5%范围内，随着十二酰基-β-环糊精添加量的增加，过滤次数相同时，对映体过量百分数(ee，%)逐渐增加。利用所制备的十二酰基-β-环糊精聚砜/手性膜，采用多级过滤装置最终实现了外消旋色氨酸的完全分离。
    Abstract: To preparate a novel polysulfone chiral membranes, β-cyclodextrin was functionalized with dodecanoyl chloride, and this modified β-cyclodextrin was then incorporated into polysulfone casting solution to form the dodecanoyl-β-cyclodextrin/polysulfone chiral membrane. Meanwhile, current studies have investigated the effect of adding different amount of dodecanoyl-β-cyclodextrin on the pure water flux, bovine serum albumin(BSA)rejection rate and enantioselectivity of the membranes. The morphology of the dodecanoyl-β-cyclodextrin/polysulfone chiral membrane was characterized by scanning electron microscopy(SEM). With the incorporation of dodecanoyl-β-cyclodextrin, the pore structure of the membrane changed significantly, with more finger-like pore structures appearing in the support layer. So the membrane water flux increased significantly, while the BSA rejection rate decreased. When the addition amount of dodecanoyl-β-cyclodextrin was in the range of 2% to 3. 5%, the enantiomeric excess increased with the addition of dodecanoyl-β-cyclodextrin. A complete separation of racemic tryptophan can be performed using this novel dodecanoyl-β-cyclodextrin/polysulfone chiral membrane-based separation system.
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  • 刊出日期:  2017-02-24

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