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儿童药物制剂掩味技术的研究进展

Advances in taste-masking technology of oral paediatric medicine

  • 摘要: 儿童对药物异味极其敏感,尤其对苦味药物的依从性很差,口服剂型的掩味与矫味策略对儿童药物制剂的研究至关重要,也是儿童药品开发的主要屏障之一。本文综述了近些年来儿童药物制剂掩味技术研究的最新进展,从药物层面、制剂层面和苦味传递层面介绍了5类掩味技术,包括其原理、特点及在药物制剂中的应用等,为掩味制剂的进一步开发提供参考。

     

    Abstract: As children are extremely sensitive to the bad taste of medicine, they have poor compliance with the bitter medicine. It is of great importance to develop the approaches of taste masking for the research of paediatric drug formulations. Besides, taste masking technology is one of the main barrier to develop children pharmaceutic preparation. This article provides an overview of the advance in taste masking technology of oral paediatric medicine in recent years, and introduces five types of taste masking technology in terms of drug, preparation and the bitter taste transduction, including principle and characteristics of these approaches, as well as their application in formulations, so as to provide some references for the development of paediatric medicine.

     

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