Abstract: Arterial thrombosis(AT)is a common disease which usually causes acute myocardial infarction, ischemic stroke and other ischemic cardiovascular and cerebrovascular diseases, which shows high rates of morbidity and mortality, and has become a serious problem to human health. It is increasingly clear that the interactions among platelets, the endothelium and leukocytes are important throughout all stages of the atherothrombotic process. It is of great significance to search for therapeutic targets in the process of AT and developing the therapeutic drugs based on those newly discovered targets. This article reviews the research advances in the discovery of antithrombotic targets and the current situation of drug development based on those antithrombotic targets found in the recent 5 years, in order to provide some references or clues for the development of innovative drugs to prevent and treat AT.