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苯硼酸类糖敏感材料在胰岛素控释系统中的应用

李丹, 付免, 钱海, 黄文龙

李丹, 付免, 钱海, 黄文龙. 苯硼酸类糖敏感材料在胰岛素控释系统中的应用[J]. 中国药科大学学报, 2017, 48(3): 259-267. DOI: 10.11665/j.issn.1000-5048.20170302
引用本文: 李丹, 付免, 钱海, 黄文龙. 苯硼酸类糖敏感材料在胰岛素控释系统中的应用[J]. 中国药科大学学报, 2017, 48(3): 259-267. DOI: 10.11665/j.issn.1000-5048.20170302
LI Dan, FU Mian, QIAN Hai, HUANG Wenlong. Phenylboronic acid-based glucose-responsive materials:synthesis and applications in insulin delivery[J]. Journal of China Pharmaceutical University, 2017, 48(3): 259-267. DOI: 10.11665/j.issn.1000-5048.20170302
Citation: LI Dan, FU Mian, QIAN Hai, HUANG Wenlong. Phenylboronic acid-based glucose-responsive materials:synthesis and applications in insulin delivery[J]. Journal of China Pharmaceutical University, 2017, 48(3): 259-267. DOI: 10.11665/j.issn.1000-5048.20170302

苯硼酸类糖敏感材料在胰岛素控释系统中的应用

基金项目: 国家自然科学基金资助项目(No.81673299,No.81273376)

Phenylboronic acid-based glucose-responsive materials:synthesis and applications in insulin delivery

  • 摘要: 近年来,葡萄糖敏感材料因在糖尿病治疗领域中的潜在应用而受到广泛关注,其中基于苯硼酸(PBA)的糖敏感材料因其稳定性、可持续响应等优点被广泛应用于自调节胰岛素控释系统中。本文主要综述了近年来基于苯硼酸的葡萄糖敏感微/纳米凝胶、自组装胶束、囊泡以及纳米粒的研究进展,并简要介绍了这些材料的制备方法。相信随着苯硼酸类糖敏感材料性能的不断优化,它将更加适合应用于胰岛素控释系统中。
    Abstract: Glucose-sensitive materials have attracted much interest due to their potential application in diabetes treatment in recent years. Phenylboronic acid-based glucose-responsive polymers, which possess continuous glucose sensitivity and good stability, have been most widely used in self-regulated insulin delivery. This review covers the recent advances in PBA-functionalized nanogels(microgels), micelles, vesicles and nanoparticles. Synthesis and application of these nanomaterials are discussed. With the development of PBA-regulated polymers, these nanomaterials will migrate from laboratory to clinical use in the near future.
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出版历程
  • 刊出日期:  2017-06-24

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