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苯硼酸类糖敏感材料在胰岛素控释系统中的应用

Phenylboronic acid-based glucose-responsive materials:synthesis and applications in insulin delivery

  • 摘要: 近年来,葡萄糖敏感材料因在糖尿病治疗领域中的潜在应用而受到广泛关注,其中基于苯硼酸(PBA)的糖敏感材料因其稳定性、可持续响应等优点被广泛应用于自调节胰岛素控释系统中。本文主要综述了近年来基于苯硼酸的葡萄糖敏感微/纳米凝胶、自组装胶束、囊泡以及纳米粒的研究进展,并简要介绍了这些材料的制备方法。相信随着苯硼酸类糖敏感材料性能的不断优化,它将更加适合应用于胰岛素控释系统中。

     

    Abstract: Glucose-sensitive materials have attracted much interest due to their potential application in diabetes treatment in recent years. Phenylboronic acid-based glucose-responsive polymers, which possess continuous glucose sensitivity and good stability, have been most widely used in self-regulated insulin delivery. This review covers the recent advances in PBA-functionalized nanogels(microgels), micelles, vesicles and nanoparticles. Synthesis and application of these nanomaterials are discussed. With the development of PBA-regulated polymers, these nanomaterials will migrate from laboratory to clinical use in the near future.

     

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