Abstract:
To study alkaloid constituents in
Corydalis decumbens, thirteen compounds were isolated from 95% ethanol extracts of
Corydalis decumbens(Thunb)Pers. by silica gel, RP-C
18, Sephadex LH-20 column chromatographer, recry stallization, thin-layer chromatography and HPLC. Their structures were elucidated on the basis of spectral data combined with physiochemical properties as tetrahydropalmatine(
1 ), oxyhydrastinine(
2 ), doryanine(
3 ), palmatine(
4 ), bicuculline(
5 ), canadine(
6 ), tetrahydrocoptisine(
7 ), corydaldine(
8 ), epicorynoxidine(
9 ),
N-methylcorydaldine(
10 ), (+)-corlumine(
11 ),
N-methyl-6, 7-dimethoxyisoquinolone(
12 )and oxysanguinarine(
13 ). Compounds
2 ,
3 ,
6 ,
7 , and
9 -
13 were isolated from this plant for the first time. In addition, compounds
2 ,
3 , and
9 -
13 were obtained firstly from this genus. Pharmacological experiments showed that tetrahydropalmatine(
1 )might have analgesic or sedative effects, and the bicuculline(
5 )could probably induce epilepsy.