夏天无中生物碱类化学成分的研究

黄启龙; 张皖晋; 李彦; 陈娟; 周宝萍; 邹筱涵; 张春磊; 曹征宇

doi:10.11665/j.issn.1000-5048.20170509

夏天无中生物碱类化学成分的研究

中国药科大学江苏省中药评价与转化重点实验室

基金项目: 国家自然科学基金资助项目(No.81473539,No.81603389)；江苏省自然科学基金资助项目(No.BK20141357,No.BK20160764,No.BK20160754)

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出版历程
- 刊出日期: 2017-10-24

Alkaloid constituents from Corydalis decumbens

摘要

摘要: 对夏天无中的生物碱类化学成分进行系统研究。通过硅胶、RP-C₁₈、Sephadex LH-20柱色谱、重结晶、薄层色谱和高效液相色谱等技术，从夏天无块茎95%乙醇提取物中分离得到13个化合物，其结构运用现代波谱技术结合理化性质分别鉴定为:四氢巴马亭( 1 )，氧化北美黄连次碱( 2 )，doryanine( 3 )，巴马亭( 4 )，毕枯枯灵( 5 )，四氢小檗碱( 6 )，四氢黄连碱( 7 )，紫堇定( 8 )，epicorynoxidine( 9 )，N-methylcorydaldine( 10 )，(+)-corlumine( 11 )，N-methyl-6，7-dimethoxyisoquinolone( 12 )和氧化血根碱( 13 )。其中化合物 2、3、6、7、9~13 为首次从该植物中分离得到，化合物 2、3、9~13 为首次从该属植物中分离得到。此外，药理实验表明，四氢巴马亭( 1 )可能具有镇痛或镇静的作用，毕枯枯灵( 5 )可能具有诱发癫痫的作用。
- 夏天无 /
- 块茎 /
- 化学成分 /
- 生物碱 /
- 分离鉴定
Abstract: To study alkaloid constituents in Corydalis decumbens, thirteen compounds were isolated from 95% ethanol extracts of Corydalis decumbens(Thunb)Pers. by silica gel, RP-C₁₈, Sephadex LH-20 column chromatographer, recry stallization, thin-layer chromatography and HPLC. Their structures were elucidated on the basis of spectral data combined with physiochemical properties as tetrahydropalmatine( 1 ), oxyhydrastinine( 2 ), doryanine( 3 ), palmatine( 4 ), bicuculline( 5 ), canadine( 6 ), tetrahydrocoptisine( 7 ), corydaldine( 8 ), epicorynoxidine( 9 ), N-methylcorydaldine( 10 ), (+)-corlumine( 11 ), N-methyl-6, 7-dimethoxyisoquinolone( 12 )and oxysanguinarine( 13 ). Compounds 2 , 3 , 6 , 7 , and 9 - 13 were isolated from this plant for the first time. In addition, compounds 2 , 3 , and 9 - 13 were obtained firstly from this genus. Pharmacological experiments showed that tetrahydropalmatine( 1 )might have analgesic or sedative effects, and the bicuculline( 5 )could probably induce epilepsy.
- Corydalis decumben /
- tubers /
- chemical constituents /
- alkaloid /
- isolation and identification

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参考文献(18)

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