Abstract: Extraction experiment of volatile compounds in disposable syringes from five manufacturers was undertaken by GC-MS with high-space injection and semi-volatile compounds were tested by GC-MS. MS detection ranged from 30 to 650 with electron ionization(EI)source. Vanillin was used as internal standard to monitor the sample pretreatment process. Liquid-liquid extraction(LLE)and solid-phase extraction(SPE)were compared to acquire a simple processing method with more extractables in syringe materials. HCl, NaOH, Tween 80 and ethanol-aqueous solution were used as extraction solvents. The method was successfully developed to determine the unknown volatile extractables and the results were used to investigate the safety of disposable syringes comprehensively.