Abstract: At present, metabolic memory is a major obstacle hindering the effective control of diabetes. Controlling blood sugar level solely by drugs can not prevent multiple diabetic complications. Understanding the molecular mechanisms of mediating diabetic complications, therefore, will eliminate the “metabolic memory” effect. In this artical, the molecular mechanism of metabolic memory mediating diabetic complications and prospective treatment drugs were reviewed, which provides basis to the further research on prevention and treatment of metabolic memory.