| [1] |
Hershko A. The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle(Nobel Lecture)[J].Angew Chem Int Ed Engl,2005,44(37):5932-5943.
|
| [2] |
Buckley DL,Crews CM.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system[J].Angew Chem Int Ed Engl,2014,53(9):2312-2330.
|
| [3] |
da Silva SR,Paiva SL,Lukkarila JL,et al.Exploring a new frontier in cancer treatment:targeting the ubiquitin and ubiquitin-like activating enzymes[J].J Med Chem,2013,56(6):2165-2177.
|
| [4] |
Bedford L,Lowe J,Dick LR,et al.Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets[J].Nat Rev Drug Discov,2011,10(1):29-46.
|
| [5] |
Wang SM, Sun W, Zhao YJ, et al. SAR405838:an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression[J].Cancer Res,2014,74(20):5855-5865.
|
| [6] |
Kee Y,Huibregtse JM.Regulation of catalytic activities of HECT ubiquitin ligases[J].Biochem Biophys Res Commun,2007,354(2):329-333.
|
| [7] |
Hatakeyama S,Nakayama KI.U-box proteins as a new family of ubiquitin ligases[J].Biochem Biophys Res Commun,2003,302(4):635-645.
|
| [8] |
Podust VN,Brownell JE,Gladysheva TB,et al.A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination[J].Proc Natl Acad Sci U S A,2000,97(9):4579-4584.
|
| [9] |
Read MA,Brownell JE,Gladysheva TB,et al.Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha[J].Mol Cell Biol,2000,20(7):2326-2333.
|
| [10] |
Soucy TA,Dick LR,Smith PG,et al.The Nedd8 conjugation pathway and its relevance in cancer biology and therapy[J].Genes Cancer,2010,1(7):708-716.
|
| [11] |
Pan ZQ,Kentsis A,Dias DC,et al.Nedd8 on cullin:building an expressway to protein destruction[J].Oncogene,2004,23(11):1985-1997.
|
| [12] |
Read MA,Brownell JE,Gladysheva TB,et al.Nedd8 modification of Cul-1 activates SCF β TrCP -dependent ubiquitination of IκBα[J].Mol Cell Biol,2000,20(7):2326-2333.
|
| [13] |
Boh BK,Smith PG,Hagen T.Neddylation-induced conformational control regulates cullin RING ligase activity in vivo[J].J Mol Biol,2011,409(2):136-145.
|
| [14] |
Xie P,Zhang MH,He SA,et al.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis[J].Nat Commun,2014,5(6183):3733.
|
| [15] |
Kumar S,Yoshida Y,Noda M.Cloning of a cDNA which encodes a novel ubiquitin-like protein[J].Biochem Biophys Res Commun,1993,195(1):393-399.
|
| [16] |
Kamitani T,Kito K,Nguyen HP,et al.Characterization of NEDD8,a developmentally down-regulated ubiquitin-like protein[J].J Biol Chem,1997,272(45):28557-28562.
|
| [17] |
Rabut G,Peter M.Function and regulation of protein Neddylation.′Protein modifications:beyond the usual suspects′ review series[J].EMBO Rep,2008,9(10):969-976.
|
| [18] |
Salon C,Brambilla E,Brambilla C, et al.Altered pattern of Cul-1 protein expression and Neddylation in human lung tumours:relationships with CAND1 and cyclin E protein levels[J].J Pathol,2007,213(3):303-310.
|
| [19] |
Mori F,Nishie M,Piao YS,et al.Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders[J].Neuropathol Appl Neurobiol,2005,31(1):53-61.
|
| [20] |
Chairatvit K,Ngamkitidechakul C.Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma[J].Mol Cell Biochem,2007,306(1):163-169.
|
| [21] |
DilKuazi A,Kito K,Abe Y,et al.NEDD8 protein is involved in ubiquitinated inclusion bodies[J].J Pathol,2003,199(2):259-266.
|
| [22] |
Li LH,Wang MS,Yu GY,et al.Overactivated Neddylation pathway as a therapeutic target in lung cancer[J].J Natl Cancer Inst,2014,106(6):dju083.
|
| [23] |
Gao Q,Yu GY,Shi JY,et al.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target[J].Oncotarget,2014,5(17):7820-7832.
|
| [24] |
Cheng F,Chen H,Zhang L,et al.Inhibition of the NEDD8 conjugation pathway by shRNA to UBA3,the subunit of the NEDD8-activating enzyme,suppresses the growth of melanoma cells[J].Asian Pac J Cancer Prev,2012,13(1):57-62.
|
| [25] |
Wang M,Medeiros BC,Erba HP,et al.Targeting protein Neddylation:a novel therapeutic strategy for the treatment of cancer[J].Exp Opin Ther Targets,2011,15(3):253-264.
|
| [26] |
Soucy TA,Smith PG,Milhollen MA,et al.An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer[J].Nature,2009,458(7239):732-736.
|
| [27] |
Zhao LP,Yue P,Lonial S,et al.The NEDD8-activating enzyme inhibitor,MLN4924,cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells[J].Expert Opin Ther Targets,2011,10(12):2415-2425.
|
| [28] |
Swords RT,Kelly KR,Smith PG,et al.Inhibition of NEDD8-activating enzyme:a novel approach for the treatment of acute myeloid leukemia[J].Blood,2010,115(18):3796-3800.
|
| [29] |
Wei DP,Li H,Yu J,et al.Radiosensitization of human pancreatic cancer cells by MLN4924,an investigational NEDD8-activating enzyme inhibitor[J].Cancer Res,2012,72(1):282-293.
|
| [30] |
Brownell JE, Sintchak MD, Gavin JM, et al. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes:the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ[J].Mol Cell,2010,37(1):102-111.
|
| [31] |
Julie LL, Sara RS, Mohsia A, et al. Identification of NAE inhibitors exhibiting potent activity in leukemia cells:exploring the structural determinants of NAE specificity[J].ACS Med Chem Lett,2011,2(8):577-582.
|
| [32] |
Heeseon A, Alexander VS. An inhibitor of ubiquitin conjugation and aggresome formation[J].Chem Sci,2015,6(9):5235-5245.
|
| [33] |
Leung CH,Chan DS,Yang H,et al.A natural product-like inhibitor of NEDD8-activating enzyme[J].Chem Commun,2011,47(9):2511-2513.
|
| [34] |
Zhong HJ,Ma VP,Cheng Z,et al.Discovery of a natural product inhibitor targeting protein Neddylation by structure-based virtual screening[J].Biochimie,2012,94(11):2457-2460.
|
| [35] |
Zhong HJ,Yang H,Chan DS,et al.A metal-based inhibitor of NEDD8-activating enzyme[J].PLoS ONE,2012,7(11):e49574.
|
| [36] |
Zhang SP,Tan JN,Lai ZH,et al.Effective virtual screening strategy toward covalent ligands:identification of novel NEDD8-activating enzyme inhibitors[J].J Chem Inf Model,2014,54(6):1785-1797.
|
| [37] |
Baell J,Walters MA.Chemistry:chemical con artists foil drug discovery[J].Nature,2014,513(7519):481-483.
|
| [38] |
Zhong HJ,Liu LJ,Chan SH,et al.Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme[J].Biochimie,2014,102(1):211-215.
|
| [39] |
Lu P,Liu XX,Yuan XR,et al.Discovery of a novel NEDD8 activating enzyme inhibitor with piperidin-4-amine Scaffold by structure-based virtual screening[J].ACS Chem Biol,2016,11(7):1901-1907.
|
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