| [1] |
Owen C,Lees EK,Grant L,et al.Inducible liverspecific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice[J].Diabetologia,2013,56(10):2286-2296.
|
| [2] |
Bakke J,Haj FG.Protein-tyrosine phosphatase 1B substrates and metabolic regulation[J].Semin Cell Dev Biol,2015,37: 58-65.
|
| [3] |
Panzhinskiy E,Hua Y,Culver B,et al.Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes[J].Diabetologia,2013,56(3):598-607.
|
| [4] |
Panzhinskiy E,Ren J,Nair S.Protein tyrosine phosphatase 1B and insulin resistance:role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis[J].PLoS One,2013,8(10):e77228.
|
| [5] |
Fernandez-Ruiz R,Vieira E,Garcia-Roves PM,et al.Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass[J].PLoS One,2014,9(2):e90344.
|
| [6] |
Barford D,Flint AJ,Tonks NK.Crystal structure of human protein tyrosine phosphatase 1B[J].Science,1994,263(5152):1397-1404.
|
| [7] |
Ozcan A,Olmez EO,Alakent B.Effects of protonation state of Asp181 and position of active site water molecules on the conformation of PTP1B[J].Proteins,2013,81(5):788-804.
|
| [8] |
Liu M,Wang L,Sun X,et al.Investigating the impact of Asp181 point mutations on interactions between PTP1B and phosphotyrosine substrate[J].Sci Rep,2014,4:5095.
|
| [9] |
Brandão TA,Hengge AC,Johnson SJ.Insights into the reaction of protein-tyrosine phosphatase 1B:crystal structures for transition state analogs of both catalytic steps[J].J Biol Chem,2010,285(21):15874-15883.
|
| [10] |
Wiesmann C,Barr KJ,Kung J,et al.Allosteric inhibition of protein tyrosine phosphatase 1B[J].Nat Struct Mol Biol,2004,11(8):730-737.
|
| [11] |
Li S,Zhang J,Lu S,et al.The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B[J].PLoS One,2014,9(5):e97668.
|
| [12] |
Briancon N,McNay DE,Maratos-Flier E,et al.Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive,synergistic,and factor-specific roles in the regulation of body energy balance[J].Diabetes,2010,59(12):3074-3084.
|
| [13] |
Elchebly M,Payette P,Michaliszyn E,et al.Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene[J].Science,1999,283(5407):1544-1548.
|
| [14] |
Waring JF,Ciurlionis R,Clampit JE,et al.PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat[J].Mol Cell Endocrinol,2003,203(1/2):155-168.
|
| [15] |
Qian S,Zhang M,He Y,et al.Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for type 2 diabetes[J].Future Med Chem,2016,8(11):1239-1258.
|
| [16] |
Frame S,Cohen P.GSK3 takes centre stage more than 20 years after its discovery[J].Biochem J,2001,359(1):1-16.
|
| [17] |
Panzhinskiy E,Ren J,Nair S.Pharmacological inhibition of protein tyrosine phosphatase 1B:a promising strategy for the treatment of obesity and type 2 diabetes mellitus[J].Curr Med Chem,2013,20(21):2609-2625.
|
| [18] |
Dagon Y,Hur E,Zheng B,et al.p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin′s effect on food intake[J].Cell Metab,2012,16(1):104-112.
|
| [19] |
Ozcan U,Yilmaz E,Ozcan L,et al.Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes[J].Science,2006,313(5790):1137-1140.
|
| [20] |
Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling[J].Cell Metab,2012,15(5):623-634.
|
| [21] |
Agouni A,Mody N,Owen C,et al.Liver-specific deletion of protein tyrosine phosphatase(PTP)1B improves obesity- and pharmacologically induced endoplasmic reticulum stress[J].Biochem J,2011,438(2):369-378.
|
| [22] |
Liu S,Xi Y,Bettaieb A,et al.Disruption of proteintyrosine phosphatase 1B expression in the pancreas affects β-cell function[J].Endocrinology,2014,155(9):3329-3338.
|
| [23] |
Zhi Y,Gao LX,Jin Y,et al.4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B[J].Bioorg Med Chem,2014,22(14):3670-3683.
|
| [24] |
Tang YB,Liu JZ,Zhang SE,et al.3-Phenylpropanoic acid-based phosphotyrosine(pTyr)mimetics:hit evolution to a novel orally active protein tyrosine phosphatase 1B(PTP1B)inhibitor[J].ChemMedChem,2014,9(5):918-921.
|
| [25] |
Zhang X,Tian J,Li J,et al.A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance[J].Br J Pharmacol,2016,173(12):1939-1949.
|
| [26] |
Balaramnavar VM,Srivastava R,Rahuja N,et al.Identification of novel PTP1B inhibitors by pharmacophore based virtual screening,scaffold hopping and docking[J].Eur J Med Chem,2014,87:578-594.
|
| [27] |
Du Y,Ling H,Zhang M,et al.Discovery of novel,potent,selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design[J].Bioorg Med Chem,2015,23(15):4891-4898.
|
| [28] |
Liu P,Du Y,Song L,et al.Novel,potent,selective and cellular active ABC type PTP1B inhibitors containing(methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic[J].Bioorg Med Chem,2015,23(21):7079-7088.
|
| [29] |
Liu P,Du Y,Song L,et al.Discovery of novel,high potent,ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity[J].Eur J Med Chem,2016,118:27-33.
|
| [30] |
Ottanà R,Maccari R,Mortier J,et al.Synthesis,biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells[J].Eur J Med Chem,2014,71:112-127.
|
| [31] |
Meng G,Zheng M,Wang M,et al.Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one:part I[J].Eur J Med Chem,2016,122:756-769.
|
| [32] |
Ma Y,Sun SX,Cheng XC,et al.Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase[J].Chem Biol Drug Des,2013,82(5):595-602.
|
| [33] |
Tang YB,Lu D,Chen Z,et al.Design,synthesis and insulin-sensitising effects of novel PTP1B inhibitors[J].Bioorg Med Chem Lett,2013,23(8):2313-2318.
|
| [34] |
Ottanà R, Paoli P, Naß A, et al. Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B:in silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents[J].Eur J Med Chem,2017,127:840-858.
|
| [35] |
Li W,Li S,Higai K,et al.Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors[J].Bioorg Med Chem Lett,2013,23(21):5836-5839.
|
| [36] |
Sasaki T,Li W,Higai K,et al.Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors[J].Bioorg Med Chem Lett,2015,25(9):1979-1981.
|
| [37] |
Ali MY, Jannat S, Jung HA, et al. Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B[J].Chem Biol Interact,2016,252:93-101.
|
| [38] |
Cerón-Romero L,Paoli P,Camici G,et al.In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives[J].Bioorg Med Chem Lett,2016,26(8):2018-2022.
|
| [39] |
Chen J,Gao LX,Gong JX,et al.Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors[J].Bioorg Med Chem Lett,2015,25(10):2211-2216.
|
下载:
