Abstract: Alzheimer′s disease(AD)is a chronic progressive neurodegenerative disease in the elderly, which causes heavy burden for the society and family. The current drugs could only improve the cognitive symptoms in the short term, but could not reverse or stop the disease progression. In view of the complexity of AD, multi-targeted drugs could be a potential strategy for the treatment of AD. Flavonoids, widely exising in the natural world, have multiple pharmacological activities. This paper summarizes flavonoids as promising multi-targeted anti-AD candidates according to the reported references previonsly published, which could provide important evidences in the development of anti-AD durgs.