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靶向肿瘤相关成纤维细胞治疗策略的研究进展

蔡汉, 刘艳红, 殷婷婕, 周建平, 霍美蓉

蔡汉, 刘艳红, 殷婷婕, 周建平, 霍美蓉. 靶向肿瘤相关成纤维细胞治疗策略的研究进展[J]. 中国药科大学学报, 2018, 49(1): 20-25. DOI: 10.11665/j.issn.1000-5048.20180103
引用本文: 蔡汉, 刘艳红, 殷婷婕, 周建平, 霍美蓉. 靶向肿瘤相关成纤维细胞治疗策略的研究进展[J]. 中国药科大学学报, 2018, 49(1): 20-25. DOI: 10.11665/j.issn.1000-5048.20180103
CAI Han, LIU Yanhong, YIN Tingjie, ZHOU Jianping, HUO Meirong. Advances in the targeted therapy of tumor-associated fibroblasts[J]. Journal of China Pharmaceutical University, 2018, 49(1): 20-25. DOI: 10.11665/j.issn.1000-5048.20180103
Citation: CAI Han, LIU Yanhong, YIN Tingjie, ZHOU Jianping, HUO Meirong. Advances in the targeted therapy of tumor-associated fibroblasts[J]. Journal of China Pharmaceutical University, 2018, 49(1): 20-25. DOI: 10.11665/j.issn.1000-5048.20180103

靶向肿瘤相关成纤维细胞治疗策略的研究进展

基金项目: 国家自然科学基金资助项目(No.81703442)

Advances in the targeted therapy of tumor-associated fibroblasts

  • 摘要: 肿瘤相关成纤维细胞(TAFs)是肿瘤微环境(TME)中最主要的基质细胞,可通过旁分泌、直接的细胞-细胞接触、免疫调控和胞外基质重塑等方式,对肿瘤的发生、发展及转移产生重要影响,是目前广为关注的抗肿瘤新靶点。在分析TAFs在肿瘤的分布位置及独有的生物学表达基础上,对目前已报道的TAFs靶向制剂进行详细的综述和分析,以期为肿瘤的靶向治疗提供新的思路。
    Abstract: Tumor-associated fibroblasts(TAFs), the most important stromal cells of the tumor microenvironment(TME), have been found to support tumorigenesis and tumor metastasis in a variety of ways, including paracrine, direct contact with cells, immune regulation and extracellular matrix remolding. Therefore, TAFs in the TME have been an optimal target for cancer therapy. In this review, the TAFs targeted therapies are summarized to provide the new strategy for tumor treatments based on the analysis of the location and specific biological phenotypes of TAFs in tumors.
  • [1] Paget S.The distribution of secondary growths in cancer of the breast.1889[J].Cancer Metastasis Rev,1989,8(2):98-101.
    [2] Katheder NS,Khezri R,O′Farrell F,et al.Microenvironmental autophagy promotes tumour growth[J].Nature,2017,541(7637):417-420.
    [3] Ishii G,Ochiai A,Neri S.Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment[J].Adv Drug Deliv Rev,2016,99(Pt B):186-196.
    [4] Komohara Y,Takeya M.CAFs and TAMs:maestros of the tumour microenvironment[J].J Pathol,2017,241(3):313-315.
    [5] Boju P,Quan L,Zheyu N,et al.Cancer-associated fibroblasts in pancreatic adenocarcinoma[J].Future Oncol,2015,11(18):2603-2610.
    [6] Kumar MM,Davuluri S,Poojar S,et al.Role of estrogen receptor alpha in human cervical cancer-associated fibroblasts:a transcriptomic study[J].Tumour Biol,2016,37(4):4409-4420.
    [7] Harati K,Daigeler A,Hirsch T,et al.Tumor-associated fibroblasts promote the proliferation and decrease the doxorubicin sensitivity of liposarcoma cells[J].Int J Mol Biol Med,2016,37(6):1535-1541.
    [8] Fullár A, Dudás J, Oláh L, et al. Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression[J].BMC Cancer,2015,15(1):256.
    [9] Mahale J,Smagurauskaite G,Brown K,et al.The role of stromal fibroblasts in lung carcinogenesis:a target for chemoprevention[J].Int J Cancer,2015,138(1):30-44.
    [10] Arrigoni C,Luca P,Gilardi M,et al.Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases[J].Mol Cancer,2014,13(1):1-6.
    [11] Ma JC,Sun XW,Su H,et al.Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer[J].World J Gastroenterol,2017,23(28):5167-5178.
    [12] Izumi D,Ishimoto T,Miyake K,et al.CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer[J].Int J Cancer,2016,138(5):1207-1219.
    [13] Tan X,Fu Y,Chen L,et al.miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer[J].Oncotarget,2016,7(1):293-307.
    [14] Yang J,Lu Y,Lin YY,et al.Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma[J].Cancer Lett,2016,383(1):18-27.
    [15] Owusu BY,Galemmo R,Janetka J,et al.Hepatocyte growth factor,a key tumor-promoting factor in the tumor microenvironment[J].Cancers,2017,9(4):1-16.
    [16] Saito S,Morishima K,Ui T,et al.The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma[J].BMC Cancer,2015,15:82.
    [17] Richards CD.Innate immune cytokines,fibroblast phenotypes,and regulation of extracellular matrix in lung[J].J Interferon Cytokine Res,2017,37(2):52-61.
    [18] Chen B,Dai W,Mei D,et al.Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system[J].J Control Release,2016,241(1):68-80.
    [19] Koczorowska MM,Tholen S,Bucher F,et al.Fibroblast activation protein-α,a stromal cell surface protease,shapes key features of cancer associated fibroblasts through proteome and degradome alterations[J].Mol Oncol,2016,10(1):40-58.
    [20] Liao Y,Xing S,Xu B,et al.Evaluation of the circulating level of fibroblast activation protein α for diagnosis of esophageal squamous cell carcinoma[J].Oncotarget,2017,8(18):30050-30062.
    [21] Huang S,Fang R,Xu J,et al.Evaluation of the tumor targeting of a FAP-based doxorubicin prodrug[J].J Drug Target,2011,19(7):487-496.
    [22] Brennen WN, Rosen DM, Wang H, et al. Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug[J].J Natl Cancer Inst,2012,104(17):1320-1334.
    [23] Lebeau AM,Denmeade SR.Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer[J].Mol Cancer Ther,2015,14(3):659-668.
    [24] Ke MR,Chen SF,Peng XH,et al.A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy[J].Eur J Med Chem,2017,127(1):200-209.
    [25] Miao L,Wang Y,Xiong Y,et al.Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin[J].J Control Release,2015,217(1):27-41.
    [26] Sanchez-Ruiz J,Quintela-Fandino M.Targeting the tumor stroma in breast cancer[J].Curr Breast Cancer Rep,2015,7(1):71-79.
    [27] Ernsting MJ,Hoang B,Lohse I,et al.Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle[J].J Control Release,2015,206(1):122-130
    [28] Guo S,Lin CM,Xu Z,et al.Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation[J].ACS Nano,2014,8(5):4996-5009.
    [29] De Vlieghere E,Verset L,Demetter P,et al.Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics[J].Virchows Arch,2015,467(4):367-382.
    [30] Miao L,Liu Q,Lin CM,et al.Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors[J].Cancer Res,2017,77(3):719-731.
    [31] Chen B,Dai W,He B,et al.Current multistage drug delivery systems based on the tumor microenvironment[J].Theranostics,2017,7(3):538-558.
    [32] Chen B,Dai W,Mei D,et al.Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system[J].J Control Release,2016,241(1):68-80.
    [33] Chen B,Wang Z,Sun J,et al.A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts[J].Nanomedicine,2015,12(1):131-141.
    [34] Chen B,Dai W,Mei D,et al.Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system[J].J Control Release,2016,241(1):68-80.
    [35] Fang J, Xiao L, Joo K, et al. A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice[J].Int J Cancer,2016,138(4):1013-1023.
    [36] Ji T,Zhao Y,Ding Y,et al.Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation[J].Angew Chem Int Ed Engl,2016,55(3):1050-1055.
    [37] Ji T,Ding Y,Zhao Y,et al.Peptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug delivery[J].Adv Mater,2015,27(11):1865-1873.
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出版历程
  • 刊出日期:  2018-02-24

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