| [1] |
Gschwind A,Fischer OM,Ullrich A.The discovery of receptor tyrosine kinases targets for cancer therapy[J].Nat Rev Cancer,2004,4(5):361-370.
|
| [2] |
Chahrour O,Cairns D,Omran Z.Small moleculekinase inhibitors as anti-cancer therapeutics[J].Mini Rev Med Chem,2012,12(5):399-411.
|
| [3] |
Zhou W,Liu X,Tu Z,et al.Discovery of pteridin-7(8H)-onebased irreversible inhibitors targeting the epidermal growth factor receptor(EGFR)kinase T790M/L858R mutant[J].J Med Chem,2013,56(20):7821-7837.
|
| [4] |
Sun D,Yang Y,Lyu J,et al.Discovery and rational design of pteridin-7(8H)-one-based inhibitors targeting FMS-like tyrosine kinase 3(FLT3)and its mutants[J].J Med Chem,2016,59(13):6187-6200.
|
| [5] |
Ellingson RC,Henry R,McDonald FG,et al.Derivatives 3-aminopyrazinoic acid[J].J Am Chem Soc,1945,67(10):1711-1713.
|
| [6] |
Albert A,Ohta K,Studies P,et al.New routes to 4-aminopteridines via 3-(dimethylaminomethyleneamino)pyrazine-2-carbonitrile and related compounds[J].J Chem Soc,1971,22:3727-3730.
|
| [7] |
Li MD.Design,Synthesis and structure-activity-relation study of novel anti-cancer compounds targeted on protein tyrosine kinase(作用于酪氨酸激酶的抗肿瘤小分子抑制剂的设计与合成)[D].Nanjing:Southeast University,2007.
|
| [8] |
Duan C,Jia J,Zhu R,Wang J.Synthesis of N-substituted-6-alkoxypteridin-4-amine[J].J Het Chem,2012,49(4):865-872.
|
| [9] |
Traxler P, Furet P. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors[J].Pharmacol Ther,1999,82(2/3):195-206.
|
| [10] |
Lawrence DS,Niu J.Protein kinase inhibitors:the tyrosine-specific protein kinases[J].Pharmacol Ther,1998,77(2):81-114.
|
| [11] |
Stamos J,Sliwlowski MX,Eigenbrot C.Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor[J].J Biol Chem,2002,277(48):46265-46272.
|
| [12] |
Sun J,Li D,Li J,et al.Design,synthesis,biological evaluation,and molecular modeling study of 4-alkoxyquinazoline derivatives as potential VEGFR2 kinase inhibitors[J].Org Biomol Chem,2013,11(44):7676-7686.
|
| [13] |
Qin X,Li Z,Yang L,et al.Discovery of new[1,4] dioxino[2,3-f]quinazoline-based inhibitors of EGFR including the T790M/L858R mutant[J].Bioorg Med Chem,2016,24(13):2871-2881.
|
| [14] |
Debnath AK,Hansch C.Structure-activity relationship of genotoxic polycyclic aromatic nitro compounds:further evidence for the importance of hydrophobicity and molecular orbital energies in genetic toxicity[J].Environ Mol Mutagen,1992,20(2):140-144.
|
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