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青钱柳和桑叶配伍组方的降血糖作用

盛雪萍, 赵梦鸽, 蒋翠花, 张健, 殷志琦

盛雪萍, 赵梦鸽, 蒋翠花, 张健, 殷志琦. 青钱柳和桑叶配伍组方的降血糖作用[J]. 中国药科大学学报, 2018, 49(4): 463-469. DOI: 10.11665/j.issn.1000-5048.20180412
引用本文: 盛雪萍, 赵梦鸽, 蒋翠花, 张健, 殷志琦. 青钱柳和桑叶配伍组方的降血糖作用[J]. 中国药科大学学报, 2018, 49(4): 463-469. DOI: 10.11665/j.issn.1000-5048.20180412
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SHENG Xueping, ZHAO Mengge, JIANG Cuihua, ZHANG Jian, YIN Zhiqi. Hypoglycemic effect of medicinal formula composed of Cyclocarya paliurus and Mulberry leaves[J]. Journal of China Pharmaceutical University, 2018, 49(4): 463-469. DOI: 10.11665/j.issn.1000-5048.20180412
Citation: SHENG Xueping, ZHAO Mengge, JIANG Cuihua, ZHANG Jian, YIN Zhiqi. Hypoglycemic effect of medicinal formula composed of Cyclocarya paliurus and Mulberry leaves[J]. Journal of China Pharmaceutical University, 2018, 49(4): 463-469. DOI: 10.11665/j.issn.1000-5048.20180412
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青钱柳和桑叶配伍组方的降血糖作用

  • 1.

    中国药科大学中药学院中药制剂系&天然药物活性组分与药效国家重点实验室

  • 2.

    江苏省中医药研究院转化医学实验室

基金项目: 江苏省自然科学基金资助项目(No.BK20161460)；江苏高校优势学科建设工程资助项目

Hypoglycemic effect of medicinal formula composed of Cyclocarya paliurus and Mulberry leaves

摘要

    摘要
  • 摘要: 为考察青钱柳和桑叶组方的降血糖作用及安全性，以高热能饲料联合小剂量四氧嘧啶(alloxan，ALX)构建实验性糖尿病大鼠模型。各组大鼠分别给予蒸馏水(空白组、模型组)、二甲双胍(Met)、青钱柳水提物(CP)、桑叶水提物(ML)及不同比例的青钱柳和桑叶组方药物(CM1、CM2、CM3)，检测血糖、血脂、胰岛素、糖耐量以及肝肾功能指标等，评价受试样品的降血糖效果及安全性。结果显示青桑组方药物组(CM1、CM2、CM3)大鼠的空腹血糖较模型组分别下降21.64%、16%、12.55%，其中CM1组空腹血糖、糖耐量以及胰腺组织形态显著改善，降血糖作用较优。桑叶水提物组(ML)及青桑组方药物组(CM3)与模型组相比，其TC、LDL-C指标显著下降(P<；0.05)，说明其有助于糖尿病大鼠血脂水平调控。各受试药物组对肝功能指标无不良影响，肾功能指标相较于模型组下降明显，说明其具有一定缓解肾损伤的作用。以上结果提示青桑组方药物可明显降低血糖，调节糖脂代谢，安全且无不良反应。
    Abstract: The purpose of this study was to investigate the hypoglycemic effect and the safety of medicinal formula composed of Cyclocarya paliurus and Mulberry leaves. An experimental diabetic rat model was established by high energy diet plus small dosage of auoxan(ALX). At the same time, each group rats were given distilled water(blank and model), metformin(Met), Cyclocarya paliurus aqueous extract(CP), Mulberry leaves aqueous extract(ML)and the different proportions of aqueous extract mixtures of Cyclocarya paliurus and Mulberry leaves(CM1, CM2 and CM3), respectively. Fasting blood glucose(FBG), OGTT, TC, TG, LDL-C, HDL-C, insulin and liver and kidney function related index were gauged to evaluate the hypoglycemic effect and the safety of samples. The results showed that FBG level of the rats in CM1, CM2 and CM3 groups decreased 21. 64%, 16% and 12. 55%, respectively, comparing with that of model group. Moreover, FBG, glucose tolerance and pancreatic tissue morphology were remarkably improved in CM1 group. TC and LDL-C levels of rats in ML and CM3 groups decreased significantly compared with the those of Model group(P< 0. 05), which showed ML and CM3 were beneficial to regulate the blood lipid level in diabetic rats. Furthermore, all the administration groups had no adverse effect on liver function index. The down regulation of kidney function index of CP, ML, CM1, CM2 and CM3 groups comparing with model group indicated that Cyclocarya paliurus and Mulberry leaves could alleviate the injury of liver and kidney. Our results demonstrated that the medicinal formula composed of Cyclocarya paliurus and Mulberry leaves were favorable to reduce blood glucose and can regulate lipid metabolism without liver and kidney toxicity.
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  • [1] Brownlee M.The pathobiology of diabetic complications[J].Diabetes,2005,54(6):1615-1625.
    [2] World Health Organization.Global report on diabetes[R].Geneva:WHO,2016.
    [3] Xu SS,Zhang HB,Zhou JP,et al.Advances of new antidiabetic drugs[J].J China Pharm Univ(中国药科大学学报),2011,42(2):97-106.
    [4] Stark Casagrande S,Fradkin JE,Saydah SH,et al.The prevalence of meeting A1C,blood bressure,and LDL goals among people with diabetes,1988-2010[J].Diabetes Care,2013,36(8):2271-2279.
    [5] Evans JM,Ogston SA,Emslie-Smith A,et al.Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes:a comparison of patients treated with sulfonylureas and metformin[J].Diabetologia,2006,49(5):930-936.
    [6] Wu TZ,Trahair LG,Little TJ,et al.Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes[J].Diabetes Care,2017,40(5):702-705.
    [7] Dai WB,Quan XM,Li LY.Pharmacological research progress of herbal formula in treating diabetes[J].World Chin Med(世界中医药),2016,11(6):1122-1125.
    [8] Lu HJ,Jin YZ,Xu QS.Effect of Qianjinwenwutang on blood glucose and renal function of diabeticnephropathy rats[J].Shandong Med J(山东医药),2014,54(33):17-19.
    [9] Ling QD.The advantages of Chinese medicine in treating diabetes[J].Her Med(医药导报),2015,34(Suppl):71-72.
    [10] Shin SO,Seo HJ,Park H,et al.Effects of Mulberry leaf extract on blood glucose and serum lipid profiles in patients with type 2 diabetes mellitus:a systematic review[J].Eur J Integr Med,2016,8(5):602-608.
    [11] Kurihara H,Fukami H,Kusumoto A,et al.Hypoglycemic action of Cyclocarya paliurus(Batal.)Iljinskaja innormal and diabetic mice[J].J Agricul Chem Society Japan,2003,67(4):877-880.
    [12] Wang QQ,Jiang CH,Fang SZ,et al.Antihyperglycemic,antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats[J].J Ethnopharmacol,2013,150:1119-1127.
    [13] Tian S,Tang M,Zhao B.Current anti-diabetes mechanisms and clinical trials using Morus alba L.[J].J Tradit Chin Med Sci,2016,3(1):3-8.
    [14] Kobayashi Y,Miyazawa M,Kamei A,et al.Ameliorative effects of mulberry(Morus alba L.)leaves on hyperlipidemia in rats fed a high-fat diet:induction of fatty acid oxidation,inhibition of lipogenesis,and suppression of oxidative stress[J].Biosci Biotech Bioch,2010,74(12):2385-2395.
    [15] Luo ML,Wu W,Liu W,et al.The therapeutic effects of different effective extracts of Mulberry leaf on type 2 diabetes mellitus rats[J].Chin Hosp Pharm J(中国医院药学杂志),2013,33(5):1221-1226.
    [16] Muoio DM,newgard CB.Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes[J].nat Rev Mol Cell Biol,2008,9(3):193-205.
    [17] CFDA. Evaluation method of antioxidant function and other 9 health function evaluation methods(The food drug safety protect(2012)No.107)[EB/OL](2012-04-23)[2017-05-01] http://samr.cfda.gov.cn/WS01/CL0847/71257.html.
    [18] YkiJärvinen H.Pathogenesis of non-insulin-dependent diabetes mellitus[J].Lancet,1994,343(8889):91-95.
    [19] Pan HM,Xu LJ,Peng Y,et al.Effects of Cyclocarya paliurus on improving HepG2 cells insulin resistance[J].World Clin Drugs(世界临床药物),2015,36(7):447-451.
    [20] Del Prato S,Marchetti P,Bonadonna RC.Phasic insulin release and metabolic regulation in type 2 diabetes[J].Diabetes,2002,51(Suppl 1):S109-S116.
    [21] Xu JF,Yi XH,Chen QB.Effect of different chemical compositions from Mulberry leaf on decreasing glucose in blood[J].Guihaia,2010,30(2):284-286.
    [22] Wu J,Shi S,Wang H,et al.Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes:a review[J].Carbohyd Polym,2016,144:474-494.
    [23] American Diabetes Association.Management of dyslipidemia in adults with diabetes[J].Diabetes Care,2002,25(Suppl 1):s74-s77.
    [24] Xie HP,Liu YN,Guo M.Experimental study of the Mulberry leaf extract′s effect on blood lipids[J].Mod Med J China(中国现代医药杂志),2006,8(11):48-49.
    [25] Li Y. Selection of oral antidiabetic drugs in type 2 diabetes patients with chronic kidney disease[J].Chin J Clinicians(中华临床医师杂志),2015,9(4):528-530.
    [26] Wang XH, Kong D, Li WZ. Effects of aqueous extracts from Morus alba leaves on blood lipids,hemagglutination,and lipid peroxidation in rats with diabeticnephropathy[J].Mod Food Sci Technol(现代食品科技),2016(6):1-6.
    [27] Chen JQ,Lin SJ,Zheng N.Effects of polysacchrides from mulberry leaves on diabeticnephropathy mice[J].Chin Hosp Pharm J(中国医院药学杂志),2016,36(10):806-809.
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  • 刊出日期:  2018-08-24

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