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2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应

陈海涛, 路小非, 韩福娇, 王文新, 傅经国, 陈辉

陈海涛, 路小非, 韩福娇, 王文新, 傅经国, 陈辉. 2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应[J]. 中国药科大学学报, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506
引用本文: 陈海涛, 路小非, 韩福娇, 王文新, 傅经国, 陈辉. 2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应[J]. 中国药科大学学报, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506
CHEN Haitao, LU Xiaofei, HAN Fujiao, WANG Wenxin, FU Jingguo, CHEN Hui. Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate[J]. Journal of China Pharmaceutical University, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506
Citation: CHEN Haitao, LU Xiaofei, HAN Fujiao, WANG Wenxin, FU Jingguo, CHEN Hui. Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate[J]. Journal of China Pharmaceutical University, 2018, 49(5): 553-557. DOI: 10.11665/j.issn.1000-5048.20180506

2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应

基金项目: 国家自然科学基金资助项目(No.21502045);河南省科技开放合作项目资助项目(No.182106000015)

Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate

  • 摘要: 以单齿磷配体(S)-MonoPHOS和[Rh(COD)2]BF4作为催化剂,研究2-酰氨基-3-芳基丙烯酸甲酯类化合物中的氨基保护基对其不对称催化氢化反应的影响。最终经水解等操作,2-酰氨基-3-芳基丙烯酸甲酯类化合物的不对称氢化反应以63%~92%的收率得到相应的D-苯丙氨酸及其衍生物。
    Abstract: By using(S)-MonoPHOS and [Rh(COD)2]BF4 as catalyst, the asymmetric hydrogenation reactions of methyl-2-acylamino-3-arylacrylate and the effect of different amino protective groups on hydrogenation efficacy were studied. The products resulting from asymmetric hydrogenation were hydrolyzed by hydrochloric acid, and the corresponding amino acids were obtained at yields of 63%- 92%.
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  • 刊出日期:  2018-10-24

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