2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应

Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate

摘要: 以单齿磷配体(S)-MonoPHOS和［Rh(COD)₂］BF₄作为催化剂，研究2-酰氨基-3-芳基丙烯酸甲酯类化合物中的氨基保护基对其不对称催化氢化反应的影响。最终经水解等操作，2-酰氨基-3-芳基丙烯酸甲酯类化合物的不对称氢化反应以63%~92%的收率得到相应的D-苯丙氨酸及其衍生物。

Abstract: By using(S)-MonoPHOS and ［Rh(COD)₂］BF₄ as catalyst, the asymmetric hydrogenation reactions of methyl-2-acylamino-3-arylacrylate and the effect of different amino protective groups on hydrogenation efficacy were studied. The products resulting from asymmetric hydrogenation were hydrolyzed by hydrochloric acid, and the corresponding amino acids were obtained at yields of 63%- 92%.