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中药及保健品中非法添加物的分析技术研究进展

侯晓芳, 施迎娣, 王嗣岑

侯晓芳, 施迎娣, 王嗣岑. 中药及保健品中非法添加物的分析技术研究进展[J]. 中国药科大学学报, 2019, 50(1): 33-40. DOI: 10.11665/j.issn.1000-5048.20190104
引用本文: 侯晓芳, 施迎娣, 王嗣岑. 中药及保健品中非法添加物的分析技术研究进展[J]. 中国药科大学学报, 2019, 50(1): 33-40. DOI: 10.11665/j.issn.1000-5048.20190104
HOU Xiaofang, SHI Yingdi, WANG Sicen. Progress in the analysis of adulterated additives in traditional Chinese medicines and health care products[J]. Journal of China Pharmaceutical University, 2019, 50(1): 33-40. DOI: 10.11665/j.issn.1000-5048.20190104
Citation: HOU Xiaofang, SHI Yingdi, WANG Sicen. Progress in the analysis of adulterated additives in traditional Chinese medicines and health care products[J]. Journal of China Pharmaceutical University, 2019, 50(1): 33-40. DOI: 10.11665/j.issn.1000-5048.20190104

中药及保健品中非法添加物的分析技术研究进展

基金项目: 国家自然科学基金资助项目(No.81673398);陕西省自然科学基金资助项目(No.2017JQ8024)

Progress in the analysis of adulterated additives in traditional Chinese medicines and health care products

  • 摘要: 近年来,中药及保健品中非法添加化学药物的事件时有发生。为此,开发快速、灵敏、准确检测非法添加物的方法和技术十分重要。通过查阅2016 - 2017年国内外发表的相关文献资料,本文从方法和技术的角度对中药和保健品中非法化学药物的分析技术研究进展进行了综述,为进一步开发快速检测新方法和新技术提供理论参考。
    Abstract: In recent years, cases of illegal addition of chemical substances into the TCMs and health-care products happened regularly. Therefore, it is particularly important to develop fast, sensitive and accurate analysis methods for detection of the adulterated chemical substances. Through literature survey of relevant papers published in 2016-2017, this article summarizes the application of various analytical techniques for adulterated chemical substances to the TCMs and health-care products with useful information for the further development of new methods and technologies in this field.
  • [1] Chen GQ,Lei Y.HPLC determination of 6 dihydropyridine chemicals in health products for anti-hypertension[J].Phys Test Chem Anal B:Chem Anal(理化检验 化学分册),2016,52(7):770-773.
    [2] Ye LH,Xu S,Wang LS,et al.Simultaneous determination of 7 antihistamine agents added into traditional Chinese medicine preparation by LC-MS/MS[J].J Pharm Anal(药物分析杂志),2016,36(11):2022-2028.
    [3] Lian YL,Du J,Qiao YF.Determination of seven yellow pigments illegally added into Chinese materia medica by HPLC-MS[J].Chin Tradit Herbal Drugs(中草药),2016,47(18):3219-3223.
    [4] Xu S,Jin PF,Xu QL,et al.Advances in the chemical substances illegally adulterated in traditional Chinese medicines and health foods[J].Chin New Drug J(中国新药杂志),2015,24(16):1843-1850.
    [5] Novakova L,Matysova L,Solich P.Advantages of application of UPLC in pharmaceutical analysis[J].Talanta,2006,68(3):908-918.
    [6] Han CX,Li Y,Li HW,et al.Establishment of detection methods for dexamethasone sodium phosphate in injections by UPLC-PDA[J].China Anim Husb Vet Med(中国畜牧兽医),2016,43(10):2748-2755.
    [7] Heo S,Yoo GJ,Choi JY,et al.A rapid method for the simultaneous determination of 25 anti-hypertensive compounds in dietary supplements using ultra-high-pressure liquid chromatography[J].Food Addit Contam A,2016,33(11):1627-1636.
    [8] Huang F,Wu HQ,Huang XL,et al.Simultaneous determination of 17 aphrodisiac chemical drugs illegally added in health products and Chinese patent medicines by high performance liquid chromatography-tandem mass spectrometry[J].Chin J Chrom(色谱),2016,34(3):270-278.
    [9] Cunliffe JM,Maloney TD.Fused-core particle technology as an alternative to sub-2-microm particles to achieve high separation efficiency with low backpressure[J].J Sep Sci,2007,30(18):3104-3109.
    [10] Lei Y,Huang T,Chen H,et al.Simultaneous rapid determination of 18 illegal additives in impotence healthy products by HPLC[J].Phys Test Chem Anal B:Chem Anal(理化检验 化学分册),2016,52(3):249-254.
    [11] He RS,Huang YT,Lei Y,et al.Rapid determination of 21 adulterants in anti-rheumatic Chinese patent drugs or dietary supplements by HPLC[J].J Instrumental Anal(分析测试学报),2016,35(11):1486-1490.
    [12] Deng M,Zhu B,Yin YH,et al.Rapid HPLC testing method for lipid-regulating drugs illegally added in traditional Chinese medicines and health food[J].J Pharm Anal(药物分析杂志),2016,36(9):1639-1647.
    [13] Gong X,Lu L,Feng YL,et al.Determination of 37 drugs illegally added in weight-losing,lipid-lowering and laxative health foods by UPLC-MS/MS[J].J Pharm Anal(药物分析杂志),2016,36(5):918-928.
    [14] Huang YY,Tu JH,Xu HX,et al.Rapid determination of 17 anti-inflammatory and analgesic chemicals illegally added into Chinese patent medicine and health foods by UPLC-MS/MS[J].Chin Tradit Herbal Drugs(中草药),2016,47(2):246-254.
    [15] Zhan SY,Zhu QF,Xu HX,et al.Rapid determination of 15 chemical drugs illegally added into slimming Chinese patent medicines and health foods by UPLC-MS/MS[J].Chin Tradit Herbal Drugs(中草药),2016,47(17):3023-3031.
    [16] Qian YF,Jia PC,Lu F,et al.Rapid determination of 38 glucocorticoids iIllegally added into Chinese patent medicines and dietary supplements by UPLC-MS-MS[J].Chin J Exp Tradit Med Form(中国实验方剂学杂志),2016,22(10):60-66.
    [17] Liu Y,Ding T,Liao XQ,et al.Direct determination of 42 chemical drugs illegally added in herbal medicines and dietary supplement by high performance liquid chromatography-quadrurpole/electrostatic field orbitrap high resolution mass spectrometry[J].Chin J Anal Chem(分析化学),2016,44(3):423-429.
    [18] Zhu WX,Liu YF,Sun ZL,et al.Simultaneous determination of 26 illegal additives in health-care food by UHPLC-MS/MS[J].Phys Test Chem Anal B:Chem Anal(理化检验 化学分册),2016,52(11):1286-1291.
    [19] Wang L.UPLC-MS/MS determination of seven illegally added chemical sedatives in health-care food[J].Phys Test Chem Anal B:Chem Anal(理化检验 化学分册),2016,52(6):629-634.
    [20] Lin F, Li T, Wang YX, et al. Simultaneous determination of 13 illegally added chemical drugs in hypoglycemic health foods by ultra performance liquid chromatography[J].Food Sci(食品科学),2016,37(18):178-184.
    [21] Olsen JV,Godoy LMF,Li GQ,et al.Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap[J].Mol Cell Proteomics,2005,4(12):2010-2021.
    [22] Makarov A,Denisow E,Kholomeev A,et al.Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer[J].Anal Chem,2006,78(7):2113-2120.
    [23] Zhong T,Zhang ZL,Zhang H,et al.Analysis of navel orange juice components by wooden-tip electrospray mass spectrometry[J].J Mass Spectrom(质谱学报),2016,37(1):75-81.
    [24] Cooks RG,Ouyang Z,Takats Z,et al.Ambient mass spectrometry[J].Science,2006,311(5767):1566-1570.
    [25] Yang YY,Deng JW,Yao ZP.Pharmaceutical analysis by solid-substrate electrospray ionization mass spectrometry with wooden tips[J].J Am Soc Mass Spectr,2014,25(1):37-47.
    [26] Hu B,Huang YY,Yin G,et al.Rapid detection of adulterated drugs in herbal dietary supplements by wooden-tip electrospray ionization mass spectrometry[J].Analytical Methods,2016,8:6840-6846.
    [27] Hubert P,Nguyen-Huu JJ,Boulanger B,et al.Harmonization of strategies for the validation of quantitative analytical procedures-A SFSTP proposal-part II[J].J Pharm Biomed,2007,45(1):70-81.
    [28] Hill HH,Siems WF,Stlouis RH,et al.Ion mobility spectrometry[J].Anal Chem,1990,62(23):1201A-1209A.
    [29] Feng X,Yin LH,Jin SH,et al.Rapid detection of undeclared phosphodiesterase type 5 inhibitors in dietary supplements by ion mobility spectrometry[J].J Pharm Anal(药物分析杂志),2016,36(2):313-320.
    [30] Jiao JD,Li JQ,Wang JF,et al.Rapid detection of illegally added barbiturates in sleep-improving healthy foods by ion mobility spectrometry[J].J Pharm Anal(药物分析杂志),2016,36(2):321-329.
    [31] Paraschos S,Magiatis P,Gikas E,et al.Quality profile determination of Chios mastic gum essential oil and detection of adulteration in mastic oil products with the application of chiral and non-chiral GC-MS analysis[J].Fitoterapia,2016,114:12-17.
    [32] Kneipp K,Wang Y,Kneipp H,et al. Single molecule detection using surface-enhanced Raman scattering(SERS)[J].Phys Rev Lett,1997,78(9):1667-1670.
    [33] Wang L,Chen MY,Li X,et al.Rapid detection of chemical drugs in antipsychotic traditional Chinese medicines by TLC-SERS[J].Res Explor Lab(实验室研究与探索),2016,35(5):22-26.
    [34] Wang L,Wang X,Tian JM,et al.Surface-enhanced raman spectroscopy(SERS)assay method for pioglitazone hydrochloride,rosiglitazone hydrochloride and phenformin hydrochloride in health care products[J].Sci Tech Food Ind(食品工业科技),2016,37(13):295-298,303.
    [35] Zhang JH,Wang HQ,Xu L,et al.Inspection of illegally added medicine in anti-fatigue health food by raman spectroscopy[J].Chin J Light Sct(光散射学报),2016,28(3):226-229.
    [36] Marshall CP,Javaux EJ,Knoll AH,et al.Combined micro-fourier transform infrared(FTIR)spectroscopy and micro-raman spectroscopy of proterozoic acritarchs:a new approach to palaeobiology[J].Precambrian Res,2005,138(3/4):208-224.
    [37] Xu F,Feng Y,Fu S,et al.Determination of fenfluramine hydrochloride added illegally into anti-obesity and healthcare food by TLC-Micro IR method[J].Chin Hosp Pharm J(中国医院药学杂志),2016,36(5):358-361.
    [38] Hachem R,Assemat G,Martins N,et al.Proton NMR for detection,identification and quantification of adulterants in 160 herbal food supplements marketed for weight loss[J].J Pharmaceut Biomed,2016,124:34-47.
    [39] Hebert PDN,Penton EH,Burns JM,et al.Ten species in one:DNA barcoding reveals cryptic species in the neotropical skipper butterfly astraptes fulgerator[J].Proc Natl Acad of Sci U S A,2004,101(41):14812-14817.
    [40] Ling HY,Tang Y,Zhu N,et al.Detecion of 24 chemical substances that illegally added into antihypertensive traditional Chinese patent medicines by HPLC-Q-TOF-MS/MS[J].J Chin Pharm(中国药房),2016,27(33):4712-4715.
    [41] Chen L,Wen JX,Qi CY,et al.Rapid detection and conformation of 21 illegal chemical drugs in anti-hyertension traditional Chinese medicine and healthy food[J].J Instrumental Anal(分析测试学报),2016,35(8):937-942.
    [42] Zhang J,Ding T,Liu Y,et al.Direct determination of 9 illegal added anti-impotence medicines in dietary supplement by UPLC-MS /MS[J].Environ Chem(环境化学),2016,35(2):415-418.
    [43] Ma CY,Feng SH,Feng L,et al.Detection of fluoxetine illegally added into slimming products by LC-MS[J].Chin Tradit Pat Med(中成药),2016,38(5):1056-1061.
    [44] Lu H,Qian YF,Zhang B,et al.Determination of anthraquinones and illegal addition of chemical drugs in diet foods[J].Sci Tech Food Ind(食品工业科技),2016,37(10):88-93.
    [45] Meng L,Chen W,OUYang BS,et al.Simultaneous determination of 9 illegally added anti-diabetic chemical components in Chinese patent medicines by HPLC-MS[J].Chin J Exp Tradit Med Form(中国实验方剂学杂志),2016,22(19):66-69.
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  • 刊出日期:  2019-02-24

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