Abstract:
Five compounds were isolated from the petroleum ether extract of
Dictamnus dasycarpus using various chromatographic techniques, such as column chromatography over silica gel and Sephadex LH-20. Their structures were elucidated by spectroscopic data(IR, MS, NMR), which were identified as docosanol(
1 ), ethyl 2, 2-dibenzhydryl-3, 3-di-phenylpropionate(
2 ), limonin(
3 ), obacunone(
4 )and dictamnine(
5 ). Compound
2 was a new compound and compound
1 was isolated from this plant for the first time. PNPG method was used to determine
α-glucosidase inhibitory activity of these compounds. The results indicated that compounds
3 -
5 possessed stronger inhibitory activities than the positive control of acarbose, which provided a theoretical basis for further development and utilization of
Dictamnus dasycarpus.