白鲜皮化学成分及其<i>α</i>-葡萄糖苷酶抑制活性

杨晓军; 艾凤凤; 蔺军兵; 汤江江

doi:10.11665/j.issn.1000-5048.20190105

白鲜皮化学成分及其α-葡萄糖苷酶抑制活性

1.
延安大学化学与化工学院
2.
延安市分析技术与检测重点实验室
3.
西北农林科技大学化学与药学院

基金项目: 国家自然科学基金资助项目(No.31860089)；延安市科技局资助项目(No.2017KS-18)；国家级大学生创新创业训练计划资助项目(No.201810719032)

计量
- 文章访问数: 788
- HTML全文浏览量: 1
- PDF下载量: 980
出版历程
- 刊出日期: 2019-02-24

Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity

摘要

摘要: 采用硅胶、凝胶柱色谱方法对白鲜皮(Dictamnus dasycarpus)的化学成分进行分离纯化。从其石油醚部位分离得到了5个化合物，利用IR、MS和NMR等技术对分离得到的化合物进行了结构鉴定。5个化合物的结构分别为:二十二烷醇( 1 )、2，2-二二苯甲基-3，3-二苯基丙酸乙酯( 2 )、柠檬苦素( 3 )、黄柏酮( 4 )和白鲜碱( 5 )。其中化合物 2 为新化合物，化合物 1 首次从该植物中分离得到。采用PNPG 法筛选化合物的α-葡萄糖苷酶抑制活性。结果表明化合物 3 ~ 5 表现出较好的α-葡萄糖苷酶的抑制活性。该结果为白鲜皮的深度开发利用提供了理论依据。
- 白鲜皮 /
- 化学成分 /
- α-葡萄糖苷酶 /
- 抑制活性 /
- 糖尿病
Abstract: Five compounds were isolated from the petroleum ether extract of Dictamnus dasycarpus using various chromatographic techniques, such as column chromatography over silica gel and Sephadex LH-20. Their structures were elucidated by spectroscopic data(IR, MS, NMR), which were identified as docosanol( 1 ), ethyl 2, 2-dibenzhydryl-3, 3-di-phenylpropionate( 2 ), limonin( 3 ), obacunone( 4 )and dictamnine( 5 ). Compound 2 was a new compound and compound 1 was isolated from this plant for the first time. PNPG method was used to determine α-glucosidase inhibitory activity of these compounds. The results indicated that compounds 3 - 5 possessed stronger inhibitory activities than the positive control of acarbose, which provided a theoretical basis for further development and utilization of Dictamnus dasycarpus.
- Dictamnus dasycarpus /
- chemical constituents /
- α-glucosidase /
- inhibitory activity /
- diabetes

HTML全文

参考文献(13)

[1]	Xu SS,Zhang HB,Zhou JP,et al.Advances of new antidiabetic drugs[J].J China Pharm Univ(中国药科大学学报),2011,42(2):97-106.
[2]	Lyann S,Kumarasamy J,Sankar M,et al.New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes:structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulate[J].Biochemistry,2010,49(3):443-451.
[3]	Avogaro A,Fadini GP.The effects of dipeptidyl peptidase-4 inhibition on microvascular diabetes complications[J].Diabetes Care,2014,37(10):2884-2894.
[4]	Lin YP,Zong YL,He H,et al.Chemical constituents of the aerial parts of Seseli yunnanense Franch[J].Nat Prod Res Dev(天然产物研究与开发),2007,19:798-800,836.
[5]	Qu JY,Wang MY,Wang CM,et al.Anti-inflammatory fraction and chemical constituents of Hosta plantaginea[J].Chin Tradit Herb Drugs(中草药),2011,42(2):217-221.
[6]	Andrew PB III,Klaus D,Rosalind YW.Isolation and identification of the first C-17 limonin epimer,epilimonin[J].J Agric Food Chem,2008,56(14):5595-5598.
[7]	Bai YY.Studies on chemical constituents and bioactivities from the root bark of dictamnus dasycarpus(白鲜皮化学成分和药理活性研究)[D].Jinan:Jinan University,2014.
[8]	Li X,Tang HZ,Gou XJ,et al.Study on chemical constituents of the root of Dictamnus dasycarpus[J].Chin Med Mat J(中药材),2008,31(12):1816-1819.
[9]	Jeong SY,Sang HS,Young CK,et al.Neuroprotective limonoids of root bark of Dictamnus dasycarpus[J].J Nat Prod,2008,71(2):208-211.
[10]	Liu ZL,Xu YJ,Wu J,et al.Feeding deterrents from Dictamnus dasycarpus turcz against two stored-product insects[J].J Agric Food Chem,2002,50(6):1447-1450.
[11]	Kang SL,Wang SX,Zhu TR.Studies on active constituents of the root bark of Dictamnus dasycarpus Turcz[J].J Shenyang Coll Pharm(沈阳药学院学报),1983,6:11-16.
[12]	Fauvel MT,Gleye J,Moulis C,et al. Alkaloids and flavonoids of Melicope indica[J].Phytochemistry,1981,20(8):2059-2060.
[13]	Kazeem MI,Ogunbiyi JV,Ashafa AO.In vitro studies on the inhibition of α- amylase and α-glucosidase by leaf extracts of Picralima nitida(Stapf)[J].Trop J Pharm Res,2013,12(5):719-725.

施引文献

资源附件(0)

计量

文章访问数: 788
HTML全文浏览量: 1
PDF下载量: 980
被引次数: 0

白鲜皮化学成分及其α-葡萄糖苷酶抑制活性

计量

出版历程

Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity

计量

出版历程

目录